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Yet Another Value Podcast · · 47 分钟

Theravance 的战略审查:与 Andy Summers 对谈 $TBPH

Andrew WalkerAndy Summers

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TL;DR
  • 主持人和嘉宾都持有 Theravance($TBPH)多头仓位,认为正在加速推进的战略审查实际上是在为出售铺路,而现金为下行风险托底。 Andy Summers(Summers Value CIO)是在公司唯一一款管线药物 III 期试验失败当天买入的。Summers 将股价跌幅描述为约30%–35%;Walker 说股价从20美元出头跌至13–14美元,而 Summers 另称是从“20美元出头跌至约25美元”。公司当天发布的公告反复提到“紧迫性”和“加速”,而审查委员会已经运行约15个月。
  • 这笔交易的非对称性来自资产负债表:按完全摊薄口径计算,市值约8.25亿美元(约5600万股),对应约4亿美元现金,以及2027年初高度可能收到的最后1亿美元 Trelegy 里程碑付款,备考企业价值约3.25亿美元。 Trelegy 这笔款的门槛是 GSK 只需让药品在2026年增长2%,而该药去年增长了15%;Summers 称这“几乎是板上钉钉”。
  • Yupelri 是一款用于 COPD、每日1次雾化给药的 LAMA,与 Viatris 按35/65分成(Theravance拿35%),去年增长12%至约2.6亿美元,专利保护看起来可延续至2039年,8家仿制药申报方中已有7家达成和解。 随着研发开支降至零、运营开支从约1.1亿美元降至第三季度的约4000万美元,Summers 的 DCF 对美国业务现金流估值约5.25亿美元,即每股约9美元;加上每股约9美元现金,分部加总估值约18美元,而股价低于15美元,其合理价值区间为20–22美元,或有约40%–50%的上行空间。
  • 中国可能是市场错误定价的增量期权:Theravance 以零费用收取纯 royalty,由 Viatris 负责商业化;Summers 称 Viatris 是中国第8大跨国药企,拥有4000多名销售代表,面对的是超过1亿名 COPD 患者的市场,而美国约为2000万。 Summers 认为,这款药“随着时间推移完全可能成为一款数亿美元级别的药物”,并可能为 TBPH 增加约2亿美元价值;Walker 承认自己此前只按小额里程碑付款,把中国业务价值近似计为零。
  • Summers 基于历史交易的模式识别判断,Viatris 很可能收购这项资产:此前 royalty 交易往往以大幅溢价完成,包括 BioSpecifics/Endo 约88%的溢价、Emisphere/Novo Nordisk,以及 Gilead 上月斥资约80亿美元、以约70%溢价收购 Arcellx。 Viatris 年自由现金流超过20亿美元,但增长资产不多,一笔5亿–6亿美元的支出就能将 Yupelri 的经济利益并入自身损益表;Walker 以 Sage 被 Supernus “基本按净现金价格”收购提出赢家诅咒反驳,Summers 则称这“更多是理论风险,而非什么实质风险”。
  • 另一个隐藏资产是约26亿美元的爱尔兰税务属性,适用12.5%的税率;拥有爱尔兰业务的买家——潜在包括通过 Mylan 获得相关能力的 Viatris——可以利用它,价值“还要再增加1亿美元以上”。
  • 如果交易没有落地,股价初期会下跌,但下行仍有相对充分的保护:约5亿美元现金、在中国业务贡献之前预计每年6000万–7000万美元的经营现金流(Summers 将其视为自由现金流)、可能的管理层更替,以及一笔大额要约回购;Walker 勾勒的方案是“返还2.5亿美元资本”。 时间上,Summers 认为在预计5月7日–8日财报日前宣布交易的概率为“90%”:“按他们起草那份公告的方式,我就是相信很快会有事情发生。”
摘要 · 为研究而整理的核心内容

1. III 期失败,是十年股东“泪路”上的出清事件

  • Summers 用一句话概括 Theravance:这“本质上是一家单产品制药公司”,十多年前从母公司分拆出来,与 Viatris 合作销售用于 COPD 的 Yupelri,双方按35/65分成(Theravance拿35%),Theravance 自己保留医院渠道的商业化。该药去年增长12%至约2.6亿美元,刚刚获准在中国上市。
  • 长期股价走势图“对股东而言看起来就是一条泪路”;管理层“广义上拿得过多”,却“没能把营收端增长转化为利润端盈利”。约3周前,公司唯一的在研资产——一款 III 期孤儿药——未能通过关键性试验。Summers 将股价跌幅描述为约30%–35%;Walker 说股价从20美元出头跌至13–14美元,而 Summers 另称是从“20美元出头跌至约25美元”。随后卖方机构也纷纷下调评级,堪称一次“出清事件”。
  • 治理风险之所以有所缓解,是因为2家激进投资者已经进入董事会,Walker 特别提到2022年的 Irenic campaign;前2大股东合计持有约三分之一,公司前3大股东合计接近40%。Walker 认为,破产生技公司的经典困境是“100美元现金却以60美元交易”,市场担心管理层“会把现金烧光”;但在这里,他认为一名与股东利益错位的 CEO“很快就会被架到火上烤”,风险没那么大。

2. 估值计算:约3.25亿美元企业价值,对应坚固的现金堡垒

  • Summers 先把账面摊开:完全摊薄市值约8.25亿美元,约5600万股,包含所有 RSU 和期权;3月底现金约4亿美元;2027年初还有最后1亿美元 Trelegy 里程碑付款待收,前提只是 GSK 销售的 Trelegy 在2026年增长2%,而去年增长了15%——“几乎是板上钉钉”。备考现金约5亿美元,企业价值约3.25亿美元。
  • Walker 对这种资本结构的态度坦率而矛盾:现金保护下行,但也稀释了对经营资产的敞口——“如果我的买入价中有60%是现金,那3%的仓位实际上是不是应该做成8%到9%的仓位?”Summers 承认这是“一个重要的组合管理决策……也是我讨厌的事情之一”。

3. Yupelri:专利延续至2039年,成本削到骨头,美国业务价值约5.25亿美元

  • 这款药的细分市场逻辑在于:随着 COPD 治疗转向三联干粉吸入剂,而这类设备“需要很大的肺部力量才能启动”,Yupelri 仍是唯一一款每日1次雾化给药的 LAMA。对于呼吸困难的中重度患者,它“对患者友好得多”;而在 Theravance 自己负责商业化的医院渠道,产品尤其见效。
  • Summers 认为,市场上共有8家仿制药申报方,其中7家已经和解,约定2039年上市;剩下的一家是他点名的 Mankind,目前尚未和解。因此,“我对2039年这个日期的判断可能是错的……但目前风险已经相当有限。”
  • 公司在宣布试验失败的公告中承诺将研发支出降至零,并将 SG&A 部门员工数削减一半,使年度运营开支从约1.1亿美元降至约4000万美元,自第三季度开始执行。基于这一成本结构,Summers 用一个“相当简单直接的 DCF”算出美国业务价值约5.25亿美元。Walker 的计算是:Yupelri 每股贡献略高于9美元,备考现金再贡献约9美元,分部加总价值约18美元,而股价低于15美元。

4. 中国,是美国投资者没有纳入估值的部分

  • Summers 认为中国业务具备实质价值:Theravance 不承担任何费用,只收取纯 royalty;而 Viatris——由 Mylan 与 Pfizer 的相关资产组合而来,Summers 称其为中国第8大跨国药企,拥有4000多名销售代表——将在中国推出当地首款每日1次的 LAMA。即使价格按照美国市场通常水平打约60%的折扣,中国仍是一个拥有超过1亿名 COPD 患者的市场,吸烟率超过美国2倍,而美国患者约2000万;因此“随着时间推移,这完全可能成为一款数亿美元级别的药物”,专利保护期限也类似。
  • Walker 值得保留的态度转变是:他此前把中国视作“锦上添花”,估值不到每股1美元,依据是750万美元审批里程碑,以及累计销售额达到1亿美元时的250万美元付款;现在他承认,“听起来我之前实在是过于保守了”。Summers 认为,这项机会可能增加约2亿美元价值。

5. Viatris 是最自然的买家——以及“赢家诅咒”之争

  • Summers 从过往投资中总结出的模式是:合作方往往会以大幅溢价买断 royalty 相关经济权益。BioSpecifics 被 Endo 以“88%的溢价”收购;Emisphere 的口服 semaglutide royalty 公司被 Novo Nordisk 收购;就在上个月,Gilead 以接近80亿美元、约70%的溢价收购 Arcellx,实质上买断了一款尚未上市药物的未来经济权益。
  • Viatris 收购的逻辑在于,将 Yupelri 的经济利益并入自身损益表,对一家增长资产不多、预计今年自由现金流超过20亿美元的公司来说,是“一项风险极低的资本配置机会”。Viatris 在前一周的分析师日上也强调了业务发展和资本配置,一笔5亿–6亿美元的支票“完全可以承担”。
  • Walker 通过 Sage 讲述了自己的反驳:每个潜在竞争买家都会担心自己压过了自然买家——“如果他们报出的价格低于我的出价,那他们肯定知道一些我不知道的事”。最终 Sage 被 Supernus “基本按净现金价格”收购,后来又有了重磅药 Zerzuvae;Walker 说,“我还是无法理解 Biogen 为什么没有转身把它买下来。”
  • Summers 的回应是,进入真实竞价流程后,“你不知道其他竞买方在哪里……我认为这更多是理论风险,而非实质风险”。潜在买家不止 Viatris,还包括 Royalty Pharma 和 HealthCare Royalty;医院销售团队并非买家的“正中球道”,但并非无法管理;如果买方拥有可比的销售团队,就能在第一天削减管理开支并实现额外协同。即便最后是低价成交也可以接受:“假设我们只拿到25%的溢价,但交易在未来几个月内完成……按时间加权的回报计算,我们俩都能接受。”

6. 爱尔兰税务属性、无交易情景,以及财报前90%的交易概率

  • Summers 对“市场遗漏了什么”的第二个回答是约26亿美元的爱尔兰税务属性,类似 NOL,适用爱尔兰12.5%的税率;如果买方能够使用它,可能“还要再增加1亿美元以上的价值”。“如果我没记错,Mylan 是一家爱尔兰公司”,因此 Viatris 可能以其他买家无法做到的方式将其变现;但这项资产“很模糊……人们很难真正理解它”。
  • 无交易情景也需要正面面对:随着事件驱动资金退出,股价“短期内可能下跌”;但在约5亿美元现金之上,公司预计每年还能产生6000万–7000万美元经营现金流,4到5年后可能继续积累现金。Walker 认为 CEO Rick Winningham“不适合”主导这一情景,Summers 也同意管理层可能随之更换。Walker 勾勒的方案是返还2.5亿美元资本,可能通过要约回购完成,同时转向 royalty,并通过创造性的 IP 结构利用这项税务属性。
  • 在财报日期前被问到时——Walker 认为日期应为5月7日或8日——Summers 表示,财报前宣布交易的概率为“90%”:“我在2家上市公司董事会任职……我知道这些公告会受到多么严格的审查……按他们起草那份公告的方式,我就是相信很快会有事情发生。”他的保留意见是,地缘政治混乱可能让进程暂停;Walker 则反驳称,一项正在增长、易于建模且由合作方商业化的资产不应因此停滞,“无论出于什么原因暂停,都会令人震惊”。
完整逐字稿
Andrew Walker

You're about to listen to the Yet Another Value Podcast with your host, me, Andrew Walker. Got a great one today, I think. I say that about all of them, but I actually it's one that's kind of unique. This is a company, full disclosure, I have a pretty pretty big position in. So, well, you can hear about why I have a position in why Andy Summers, the CIO of Summers Value, why he has a position in it. You can hear all that. You've got that disclosure out the way. The disclaimer that nothing on this podcast is investing advice always applies. Full disclaimer at the end of the podcast, but uh you know, I think it's a fascinating idea and I think it's particularly fascinating because the risk reward, the downside is very very well protected in my opinion, but you're going to hear all of that in the podcast. So, we'll get there in 1 second, but first, a word from our sponsors. This podcast is sponsored by Trada. Look, I've been meant You've heard me talking about Trada for months on this podcast. There's a reason. It is a really really good fit for you if you like this podcast. Trada is a interviews between two buysiders who are talking about stocks they like. Sometimes you get a bear and a bear, sometimes you get a bull and a bull, sometimes you get a bull and a bear. Whatever it is, it is two buysiders who are interested enough in a stock that they've done research and they want to go on and talk to someone else about the stock and you kind of be going to be a fly on the wall and listen and learn. I'll tell you what, I am recording this in the middle of February. It has been the SAS-pocalypse and Trada has been so so good. So many different companies are covered and you know, in real time you're seeing people talk about, "Hey, is the AI risk real here? Hey, I talked to a CIO of a company who, you know, they were looking into this and they don't need this anymore. Hey, I talked to a CIO who said there is no chance in hell that we will get off of this product. So, I I just think Trada, if you have not tried it, you should try it. The most frequent feedback I get from people who try it through this podcast, they come to me and say, "Hey, I really like it. I wish there was more of it. I wish there were more coverage. I love it." So, look, if you haven't tried it, you should go to trytrada.com. That's try t r y trada t r a t a dot com and go check it out. All right, hello and welcome to the Yet Another Value Podcast. I'm your host, Andrew Walker. And with me today, I'm happy to have on another Andrew, Andy Summers from Summers Value. Andy, how's it going?

Andy Summers

It's going well. Thanks for having me on the show today.

Andrew Walker

Uh I'm super excited to have you on because we're going to talk about one of my uh you know, I'll give a full disclaimer at the start. I am long the stock. One of my favorite setups in the market right now. We'll get there in 1 second, but first, a reminder, despite the fact that I'm long the stock, you know, everyone should remember do your own do your own research. Nothing on this podcast is investing advice. There's a full disclaimer at the end of the podcast and there's always a link to the disclaimer in the show notes. All that said, Andy, the stock we're going to talk about today is Theravance. The ticker there is TBPH. I'll toss it over to you: What is Theravance, and why are they so interesting?

Andy Summers

Of course. I think I would also like to add a similar disclaimer: I also own the shares in my funds, so take what I say with a grain of salt.

Theravance is, in a nutshell, a single-product pharmaceutical company. It's been around since it was spun off from its parent company over a decade ago. Theravance sells a drug called Yupelri, which is used for COPD.

Over the last decade or so, the COPD market has evolved away from monotherapies into triple therapies. The drug that Theravance sells is a monotherapy, so it's a niche drug inside of a very large market.

They sell that with their partner, Viatris. Viatris is in charge of most aspects of the selling and marketing activities, although Theravance has carved out a small portion of the market: It's in charge of marketing the drug into the hospital setting.

They are in a long-term relationship with Viatris. They share the economics on the drug 70/30, and the drug has grown nicely over the years. I think it grew 12% last year, to roughly $260 million, so it is a growth drug.

It's approved in the U.S. and in other markets around the world. For example, it was just approved in China last year. It's going through pricing negotiations now, and it'll be on the market there shortly. It is a drug that's sold outside of the United States as well.

Andrew Walker

That's perfect. Look, as a shareholder, I'm ready for those sweet, sweet Chinese royalties to start kicking in, but maybe we should start here. If a listener who hasn't looked at this company listens to the first 2 minutes of this podcast, I know what they're going to do: They're going to pull up the stock chart and see this giant cliff that happened about 3 weeks ago. It goes from, what was it, $20 to $13 or $14, and they're going to say, "Oh, my God, what happened?"

Why don't we talk about the setup for how we got to today, and then we can circle back to Yupelri after we talk about that setup?

Andy Summers

If you go back even further, to when the company was spun out, the long-term stock chart here looks like a trail of tears for shareholders. It's been a company that has destroyed value for many years.

I would say it's a management team that is, broadly speaking, overpaid and has been underwhelming with results. There hasn't been a lot to cheer for here.

I became a shareholder recently. I bought the stock the day the news broke on the Phase 3 trial.

What happened recently was that the company had a drug in development. It was the only drug they were really developing that was in a pivotal Phase 3 study for a niche indication. It was going to be a rare orphan drug, but it failed in its Phase 3 trial.

On the news of that failure, the stock declined by 30% to 35% that day. It went from, as Andrew said, the low $20s to $25-ish a share. It was heavily sold on the bad news and was also downgraded by several sell-side firms on that news.

It was a cleansing event, if you will, for the company following the negative Phase 3 readout.

Andrew Walker

That's perfect. Before we address the value here, I think it is—you mentioned this is a trail of tears, and management is overpaid. I'm not going to disagree with you there, but I do think there's one other piece of history that's worth mentioning. That's around 2022, when people can Google "Irenic plus Theravance." Irenic gets involved, and a lot happens there, because I think the outcomes of that are really important to what's going on.

Could we just talk about that activist history here real quickly?

Andy Summers

Because of the challenges that the company has gone through over the years, it always looked like there was value here. But because they were continuing to spend money on R&D and spend too much money on SG&A, the financials never looked great. They could not translate top-line growth into bottom-line profits.

To Andrew's point, there were 2 activists who got involved here, and they both have board seats today.

I think it's also worth noting that the shareholder base is extremely concentrated. The top 2 shareholders own about a third of the company, and if you include the third-largest shareholder, it approaches almost 40% of the shares owned by those 3 parties.

It's a very concentrated shareholder base. I think we can talk more about this in a few minutes, but I think having those 2 shareholders in the boardroom is what's really going to make this process that they're going through a success.

Andrew Walker

Absolutely. You can agree or disagree with whatever you want, but if I just back up, people who listen to this podcast know I've spent a lot of time in busted biotech land. The issue is often that you've got a company with $100 of cash trading at $60.

Nobody doubts that the cash is there and that it's valuable. What everyone doubts is, "Is management going to go light that cash on fire, and how much are they going to light that cash on fire?"

What I like here is that the CEO, despite being quite overpaid at this point, has accrued quite a bit of stock, so hopefully he's aligned. Even if he's not aligned, with 3 or 4 major shareholders—and 2 of them in the boardroom—I'm hoping that he knows, "If I try to be not aligned, my feet are going to get held to the fire really quickly."

I'll pause there if you want to add anything to that.

Andy Summers

No, I think that's spot on. That is the problem here, and I guess that also becomes the opportunity for this process to yield a positive outcome.

Andrew Walker

Perfect. Let me build off what you just said: this process. They announced the drug failure and said, "We've had a strategic review committee that's been going since the end of 2024, so about 15 months. With our only growth asset, the drug, having failed, we're accelerating that process. We're cutting a bunch of costs, and we're going to accelerate the strategic review process."

I think both you and I are here for a strategic review. We see, "Hey, let's realize that asset value—sum of the parts." So let's talk about the strategic review, the sum of the parts, and all of that type of stuff.

Andy Summers

Sure. For background, I think it's important that listeners to this podcast read the press release that was issued on the day that the Phase 3 trial failed.

Andrew Walker

This is a podcast. You're going to ask people to read instead of listen?

Andy Summers

Sorry, everybody gets a little bit of homework today.

It’s one of the more interesting press releases that I’ve seen recently. Essentially, what it does is lay out the fact that the Phase 3 trial failed, but also the next steps, which in this case include a strategic review committee looking at options for the company going forward. Those options include selling the business.

They included words in the press release such as “urgency.” They said that many times, and they’re going to accelerate—that was another word they used several times—the process. As Andrew noted, the committee has been working now for some time. The first piece of action they took was selling their remaining Trelegy royalties last year.

The next step that I expect them to take will be to sell what’s left of the company, which is the Yupelri royalty stream, or the economics on Yupelri. I think that’ll be the next step. To set the table for everyone, Andrew, the market cap here today is about $825 million. I’m including all RSUs and all options, so that’s a fully diluted share count of roughly 56 million shares.

The company will end this month, March, with roughly $400 million of cash. There’s another $100 million payment due to Theravance early in 2027. It’s the final payment on Trelegy. If you read the 10-K, it’s very clear in there that the bar is really low for them to earn that final $100 million payment.

Trelegy grew 15% last year. It’s sold by GSK around the world, and it’s triple therapy for COPD. For them to earn that $100 million payment, they have to grow 2% in 2026. It’s almost inevitable that they receive the $100 million.

I’m going to say, on a pro forma basis, the company will have $500 million of cash early in 2027. It’s almost a foregone conclusion. If you take the $825 million minus $500 million, the enterprise value here is $325 million. I just wanted the listeners to understand the context.

One of the reasons I like this idea so much is the asymmetry here and the fact that our downside is protected by this enormous cash balance on the balance sheet. I think that makes this idea even more attractive.

Andrew Walker

It’s one of the things that I like, too. We’re going to talk about the sum of the parts, because once you do the cash and, as you said, the Trelegy royalties, it’s like, “Hey, my downside’s really protected.”

It’s also one of the things I least like, because I’ve had this discussion on the podcast before, in this debate with people: when you have something that’s undervalued with a lot of cash, you start getting into, “Hey, I have to have a really big position to justify that risk-reward,” or to move the needle on a risk-reward basis, if that makes sense.

If you could just strip the cash out, you could have a 3% position here and have a lot of upside. With all that cash, it’s kind of like, “Well, if 60% of my purchase price is cash, should that 3% position actually be an 8% to 9% position in order to get the same economic exposure?” If that makes sense.

Andy Summers

Yeah, I think that’s an important portfolio-management decision. It’s one of the things I hate.

Andrew Walker

Okay. You did a nice job. We’ve got the Trelegy milestones coming, we’ve got $400 million in cash, and we can talk about how they’ve cut costs and everything to get there. But let’s just dive into Yupelri, because this is the swing, right? This is the drug that they’re co-promoting. They get 35% of the economics. They do hospital, and they’ll get some international. But it is the swing.

They’re partnered with Viatris on this. I’ll ask you how you think about the value here, and then I’ve got some thoughts. Obviously, I’ve got some thoughts on that I’d love to discuss with you.

Andy Summers

I think I said 30% earlier. You’re correct: it’s 35/65, with Theravance receiving 35% of the economics in the US.

As we discussed earlier, Yupelri is a growth asset. It grew 12% last year, and it looks to me like that should continue into 2026 and beyond. They’re having a lot of success in the hospital setting, where Theravance is responsible for the marketing activities.

Yupelri is a niche product inside of the COPD market. It’s the only once-daily nebulized LAMA therapy on the market, so it’s more for moderate and severe patients. What I referenced earlier is that the market has moved over time to triple therapy, and the triple therapy is a dry-powder inhaler. It takes a lot of pulmonary effort to activate the DPI.

One of the unique attributes of Theravance’s drug is that it’s in a nebulizer, and it’s really easy for the patient to take a few breaths and deliver the medicine deep into the lungs. It’s a much more patient-friendly therapy for those who have trouble breathing. That’s the role they play in the market.

Andrew Walker

I’m laughing because Liquidia was and is a huge topic of conversation on the podcast. It has been a huge topic of conversation in the past, and people are very familiar with inhaler nebulizers from Liquidia. I just wanted to agree with that.

Let’s talk about patent protection. How long? This is a branded drug. Branded drugs eventually go generic, and the economics of them basically go to zero. What does the patent protection here look like?

Andy Summers

It looks to me like they’re going to have patent protection until 2039. The reason I say that is because there have been, I believe, 8 generic filers so far, and 7 of the 8 have settled for launch dates in 2039.

The remaining generic company, I believe, is Mankind, and it has not settled yet. There is a risk that I’m wrong about the 2039 date, but I think at this point it’s pretty minimal. It looks very likely that the drug will be protected until 2039. Then you’re going to see a flood of generics come into the market.

Andrew Walker

You’ve got—we’re in 2026, hopefully—and there is some risk of Mankind winning that. But I think it’s low when you’ve got 7 of the 8 settling. Hopefully, you’ve got about 13 years of patent protection here. Then the drug goes to zero overnight. It’s never quite overnight, but it’s pretty close to that when you’re talking about 13 years.

What is this worth? You’ve got a branded drug with a little over a decade of patent protection, growing nicely, as you mentioned—a niche drug growing nicely. Before we talk about acquisitions and everything, how do you think about the value of this drug?

Andy Summers

I think the value of the US business, the royalty stream until 2039, is roughly $525 million. One of the key points in the press release we talked about a few minutes ago, which was issued on the day the phase 3 trial failed, was that the company is going to cut R&D spending to zero. They are fully winding up their R&D activities. Then they’ll be cutting their SG&A head count in half.

Their annual spending on OpEx is going to go from roughly $110 million to roughly $40 million starting in the third quarter of this year. With that in mind, and knowing the trajectory that the drug is on, you can run a straightforward DCF calculation. I landed around $525 million.

Andrew Walker

$525 million. You mentioned earlier that there are roughly 56 million shares outstanding, all in. We’re talking about just shy of $10 per share, a little over $9 per share, of value from Yupelri.

Combine that with the roughly $500 million of cash after they get the Trelegy milestones we talked about, which again is about $9 per share, and I’ve got you at roughly $18 per share of value to TBPH. The stock’s under $15. Obviously, that’s not enormous upside. It is nice upside, but not enormous upside.

The really nice thing here is that it’s good upside with a lot of downside protection. Why don’t we talk about timing? Then I’ll come back with some other questions.

Andy Summers

Maybe I can layer in a few other things, Andrew, if that’s okay, before we move on.

Andrew Walker

I’ve got tons of questions. I’m ready. Absolutely, please.

Andy Summers

Okay. That is what I said, but I do think there are a couple of elements here that are also worth including in the valuation discussion.

First and foremost, we talked about this earlier when we started, but they’re about to launch the drug in China. One of the things that US investors tend to struggle with is market opportunities in foreign countries.

What’s interesting about China, and what I think could be a reason to add some value to the equation for China, is that Viatris is marketing it there on its own. Theravance will receive a straight royalty rate in China, which is extremely valuable. They’re going to have no expenses in China. Their partner will pay for everything.

Viatris is the 8th-largest multinational pharmaceutical company in China. Remember, Viatris was a combination of Mylan and Pfizer’s legacy pharmaceutical business. They combined to create Viatris, so they have a long history of operating in China.

They have a pretty large selling and marketing organization there that will be in charge of this asset in China. This will be the first once-daily LAMA product launched in China.

They’re going through pricing discussions right now. I’m thinking about the average here, but the average drug launched in China is priced at roughly a 60% discount relative to the US. It could be a little more or a little less, but let’s say it’s in line with the average: 60%.

But Viatris has over 4,000 sales reps in China. It's a pretty substantial sales and marketing effort there. I would also say that, for Viatris, China is one of the few markets that is growing for the company. It's a very important market for them, and I think this launch will get a lot of focus. In China, if you think about it, one of the precursors to COPD is smoking, and the incidence of smoking in China is more than 2× that in the United States.

That's created a pretty large market opportunity of over 100 million patients in China, relative to 20 million patients in the United States. I think that's important because, if you look at other surrogates—other drugs that have launched in China—this could definitely be a multi-hundred-million-dollar drug over time. They have similar patent protection in China as they do in the United States. I think this could be a piece of the puzzle that's overlooked. I do think it could add a couple hundred million dollars of value to the equation.

Andrew Walker

I'm glad you pointed that out because, again, I've done a lot of work here, and I will just tell you, I had China as kind of a cherry on top. I was putting basically no value in here, and I'll tell you why. The royalty is obviously going to be hugely valuable, but when I looked and saw, “Hey, they got a $7.5 million milestone payment from Viatris for approval in China,” I was doing that math and said, “Well, if it's only worth a $7.5 million milestone up front, they get a couple more milestones like they've got—if cumulative China-region net sales are $100 million, they get $2.5 million.”

When I was looking at those, I thought, “Well, it seemed to me like $100 million seems like a good number for them, and that's cumulative. They get 14%, that's $14 million, plus $2.5 million. That's $16 million, which is under $1 per share.” It sounds to me like I was being much too conservative with the possibility here, because if you're talking about a $100 million-plus drug, it's going to be worth multiple dollars per share for Theravance.

Perfect, which he is quite meaningful. So, look, we I laid out a some of the parts to 18, you even talked about it how it goes higher. Let's talk about the Let's talk about the running the strategic process. Everyone knows this is code for sale and you can see that through, you know, the the incentives here, the board members, the the alignment, a bunch of big shareholders who probably don't want to hold a a no-growth asset. Uh, I'd love to talk about you laid out a 525 million, uh, you call revalue excluding the China royalties, right? Well, it it does kind of take two to tango, the running strategic process. There's one really natural buyer here. How do you think the strategic process plays out, and how do you think it gets valued as they look to sell this thing? I have some commentary at the end, but I'd love to toss that question over to you.

Andy Summers

I think, as you can appreciate, Andrew, pattern recognition is one of the most important tools in our toolbox. If I apply pattern recognition to what we're looking at here with Theravance, I think there's a very strong likelihood that Viatris does acquire this asset.

My fund launched in 2018, and a couple of the companies we owned over the course of our history included 2 royalty companies similar to Theravance. They didn't have any commercial elements to their business models like Theravance does; they were just pure royalty streams.

I owned BioSpecifics, which received a royalty on a drug called XIAFLEX, which was sold by Endo. Endo ended up paying, I believe, an 88% premium to where the stock was trading in the public market at the time. I also owned a company called Emisphere, which received a royalty on oral semaglutide. If you've been paying attention to Novo Nordisk, they're launching oral Wegovy now in higher doses. It used to be called Rybelsus when it was first launched; they changed the name to oral Wegovy, but Emisphere received a royalty on that drug of 2% or 3%.

That company was acquired by Novo Nordisk. More recently—this goes to February of this year, so last month—Gilead acquired its partner. They had an oncology program with Arcellx, and they bought Arcellx for almost $8 billion. It was, again, like a 70% premium. What they did was essentially buy out the royalty stream. The drug has not launched yet, but they bought out the future royalty stream on that drug for almost $8 billion.

This is a transaction profile that I've seen many times over the course of my career. One of the hesitations that people have is, “Well, if there's only 1 bidder, why would the premium be attractive to shareholders?” That's just not really what I've seen. I've seen these companies pay pretty fair prices for these assets, and the opportunity for Viatris is to consolidate the economics of this drug onto its own P&L.

Viatris has not been a growth company historically, so I think this is one of its few growth assets. It can consolidate all the economics onto its P&L. I think it's a very low-risk capital deployment opportunity for them.

Viatris just had its analyst day last week. At that analyst day, it talked a lot about business development and capital deployment. It will generate north of $2 billion in free cash flow this year. This would probably be a $500 million or $600 million check for Viatris, but within the context of more than $2 billion of free cash flow, it's something the company could easily take on. I think it has all the motivation in the world to do it, just knowing the product profile better than anybody else.

Andrew Walker

I largely agree with you, but let me push back in 1 area. You mentioned—and you clearly knew where I was going with the pushback and incorporated it—but you've got this product, and Viatris owns 65% of it; Theravance owns 35% of it. I keep saying Viatris. You're almost certainly correct that it's Viatris. I just read this, and I'm very bad at pronunciation. But Viatris owns 65% of it, Theravance owns 35% of it.

The worry here is that you go and sell it, and you want to run a fair process and say, “Hey, anyone can come buy it.” Every buyer who comes and looks at it says—and Viatris runs this math in its head—“What if I submit the high bid? If I submit the high bid, I'm going to be very sad because there's a very natural buyer over at Viatris. If they submitted a bid underneath me, then they knew something I didn't, and I've got a real winner's-curse issue here.”

I would point to Sage Pharmaceutical, which I was very involved with last year. They have a drug that they're partnered on with Biogen, and Supernus ends up buying them. Supernus buys them for a song—basically net cash—and now it has this blockbuster Zerzuvae drug that's growing double digits year over year. I still can't understand why Biogen didn't turn around and buy them.

I guess I would just worry: I totally get what you're saying, but if I'm Viatris, I say, “No bidder is going to want to come in and put in a full price for this because they're going to wonder what I know that they don't. Because of that, I can bid kind of low, and no one else is even going to compete with me until you get to the real bottom-feeders who are just going to say, ‘I bid this for cash.’”

The last thing I would say is I completely agree with you: in the market, royalty companies that have royalty streams from big blockbuster products go for huge premiums when they sell. But often that's because of 2 things, right? Here, Theravance has already announced the strategic alternatives process. Arcellx had not announced the strategic alternatives process, so people were very surprised by the announcement.

And then, B, a lot of these companies that have big royalty streams get applied huge corporate governance discounts because people are worried about what I said when we were leading into this: “Oh my God, they’ve got literally a royalty on a $1 billion product, and they’re just going to take all that cash and say, ‘Hey, let’s buy some lottery tickets and go invest in R&D.’” Theravance doesn’t really have that risk associated with it right now because I think people think they’re aligned.

So, those would be my 2 pushbacks and the things that, as someone who owns it, personally keep me up at night a little bit about the stock. I’ll toss all that over to you.

Andy Summers

Yeah, I think those are all fair points. I think there are a couple of things I would say. First, when you’re in a bidding process, you don’t know where the other bidders are, right? So, you don’t know if you’re overbidding or underbidding, and you won’t even know that in hindsight. I think that’s more of a theoretical risk than anything else.

If you think about the universe of buyers here, obviously Viatris would be at the top of the list. It’s the most natural buyer for this asset. Could one of the royalty or pharma buyers step in here? I think they maybe could. It’s not right down the fairway for them because there’s an operational component with the hospital sales force in the U.S., but it’s a relatively small sales force, and I don’t think it’s a very complex organization to manage.

So, could they do it? Yes. Is it in the fairway? No. But they could also be in the bidding for this. If you’re another drug company that has a hospital sales force, you could obviously layer this in very easily and cut a lot of expenses potentially in the process. That’s something we haven’t talked about yet.

Yes, Theravance is cutting expenses, but could a buyer cut them even further? Of course. There’s corporate overhead that can be cut on day 1, and that’s not an insignificant number with this company. There could be even more synergy opportunity if a company has a hospital-based sales force. A company with that profile could also be in the bidding for something like this.

I don’t think it’s necessarily Viatris or bust in this situation. I think there could be other parties around the hoop who could keep them honest and force a sale price that is more in the zone of what intrinsic value is here.

Andrew Walker

Yeah, because my dream is that you run a process and Viatris pays full price, right? But your second dream is that Viatris comes in with a lot of swagger and thinks they can buy this for a song. Then the bankers go to them at the end and say, “Hey, you guys are not the high bidder. Do you want to give us your best and final before we go and sell this to a suboptimal bidder?” And Viatris says, “Oh my God, this is worth $525 million-plus to us. Here’s $500 million.”

One other thing: You mentioned royalty companies. There’s this little royalty company that’s bought a lot of my net-cash biotechs, XOMA Royalty. The ticker there is XOMA. I don’t know them super well, though I’ve read their conference calls and transcripts, and I’m kind of impressed by what they’re doing.

It’s not lost on me that in their most recent conference call, they said, “Hey, if you review the 14D-9s of a lot of these companies that are selling, that have royalties and commercial assets, you’ll see a small royalty company in their bidding. That’s us. We’re ready to take the next step if we think we can buy commercial assets for an attractive price.” So, I think there are some companies stepping out there who might be interested in this. I’ll pause there. Anything else you want to say on the sale process and buyers?

Andy Summers

Well, I think in the buyer universe, it would be one of the larger pharma companies, like Royalty Pharma or HealthCare Royalty. I don’t know that XOMA or Lagan has the balance sheet to take on something like this, but I do think the 2 big guys definitely could try.

I think there will be enough participation here that Viatris will have to stay honest in its bidding. I’ll go back to what I said before: In the press release that they put out, they said they have urgency. They said they’ve accelerated the process multiple times.

Let’s say I’m wrong. Let’s say we only get a 25% premium, but it happens in the next couple of months. I think on a time-weighted basis, we could both live with that outcome. If I’m wrong and the price is lower, but the duration is pretty short, I think we’re all going to end up in a pretty good place.

Andrew Walker

I love to ask every guest: What are you seeing that the market’s missing? I’ll ask that here because you do have a company where you can go back to the Irenic press release, when they were running an activist campaign 2½ years ago. They laid out their sum of the parts. Now, 2½ years later, some of the parts have changed, but a lot of it looks similar.

The company comes out with a press release that says, “Hey, we’re cutting expenses. Here’s what our cash flow is going to look like in Q3 and going forward once we’ve cut all these expenses. Here’s our balance sheet. We’re running a process.” It’s not a long leap for investors to do this math and figure out what the company’s worth.

The market is a very competitive place, particularly when you’ve got something this clear, where you can see where the puck is going. What do you think you—and I’ll throw myself in there—are seeing that the market is missing here?

Andy Summers

I think the first piece is the China opportunity, which I just don’t think U.S. investors probably handicap correctly.

Andrew Walker

That’s something I was not seeing for sure. We’ll see if I’m right or not.

Andy Summers

The second thing is that there’s another asset on the balance sheet. It’s sort of an NOL. It’s an Irish tax attribute, as they call it. We would call it an NOL in the U.S. The Irish tax attribute is about $2.6 billion.

The math there is that you would take the $2.6 billion, multiply it by the tax rate in Ireland, which is 12.5%, and then, of course, you have to present-value that to today. The greater question is whether the company can even use it. Do they have operations in Ireland? Are they a pharma company that can use it the way Theravance could? Those things are important.

In the case of Viatris, they have a big operation in Ireland. Mylan was an Irish company, if I remember correctly. So, they could be in a position to use those Irish tax attributes, and those could represent another $100 million-plus of value that we haven’t talked about yet.

I think that’s another piece that’s probably nebulous to investors. It’s confusing and hard to understand. Can they use it? Can they not? If they can, what’s it worth? Just knowing who the potential buyer could be, that’s another source of value that might be hard for people to ascribe value to.

I’m not trying to do that here. I don’t know what the answer is. But if it’s Viatris, I think they definitely have the potential to use that NOL in Ireland in ways that other potential buyers might not. Again, I just think those things might be difficult for people to wrap their minds around.

It’s not as straightforward as just running a simple DCF on a cash-flow stream between now and 2039. I think anybody can do that with some pretty simple assumptions. So, I think those are the things that might be misunderstood here.

Andrew Walker

That’s great. I have seen people—and I believe you; I don’t want to put words in your mouth—think this is a clear sale candidate. You’ve got an aligned board, hopefully, and a strategic process that’s gone on for 18 months. It seems clear they were waiting on the results of the Cybers trial before they decided where to go. You mentioned a few months to resolution, and I kind of think that’s right when you’ve got an asset this clean.

But I do want to ask: If they do not sell, and we hit May or June and the company says, “Hey, we’ve decided the best course of action is X,” and X is not selling to a company for $18, $20, $16—whatever the number is—what happens here?

Andy Summers

I think the stock probably goes down in the short term. I think that would be a negative news event for the market. There are a lot of event-driven investors who are probably buying the stock here, or who have bought the stock already, who would be moving on at that point.

What I would say is, if you look at the profile of the company going forward, they’ve said publicly now that they expect to generate between $60 million and $70 million of free cash flow—I guess operating cash flow, which would be free cash flow in this case. They don’t have any capex. They expect to generate $60 million to $70 million of free cash flow going forward.

You’d have a $500 million cash balance and a really attractive and growing cash-flow stream over time. Of course, that doesn’t include China yet. That’s going to kick in later this year. It also doesn’t include the interest income they’re going to earn on the $100 million Trelegy payment that they’re going to receive in early 2027.

So, it would be growing cash over time. I think the downside will be relatively limited.

If you think about it this way, with an $825 million market cap and a $500 million EV, you would earn back the entire market cap in 4 or 5 years; it would be in cash if they didn't do anything with it. So I think you're relatively protected, even though the stock would probably go down in the short term. I don't think it goes down a lot, but that would be a negative event if it were to occur.

Andrew Walker

I would not like to live in that world, for sure, but people have brought up that the person who's leading the strategic review committee has a background at Royalty Pharma. You could imagine a scenario where, if for some reason my worry comes to pass and biotech just does not play ball and says, “Hey, that $500 million-plus you probably have, we're going to bid $200 million on it,” no one else plays because everyone else says, “If biotech doesn't want it, we don't want it.”

I could imagine a world where they say, “Hey, we've got $500 million of cash. We have a hospital sales force. We've got growing Yupelri. We are going to become a royalty play. And the nice thing is, we can help monetize things through our hospital sales force if we need to. And we've got the $2.6 billion of NOLs that you mentioned, where if we buy and structure the IP creatively, we're not going to be a taxpayer.”

Is that a world I want to live in? No. But I don't think it's going to be a nice mark on day 1. On day 181, I don't think there's that much downside from the current share price. In fact, I still think we could realize the full value, and then the NOLs do start taking their place. So if you have any thoughts on that, or if I'm just talking myself into thinking the downside isn't that bad, Andrew, you can tell me that, too.

Andrew Walker

I think in that scenario you'd probably see a regime change on the management team as well. I don't think CEO Rick Winningham would be long in the tooth for this business. He would not be the right guy for that.

Andy Summers

Absolutely. Exactly. So I think you would see some change in management alongside that. I don't know what that would look like, but I don't think that's a world that anybody would prefer. At the same time, we have to prepare for that, right? As investors, it is in the range of outcomes.

I just think that, given the balance sheet strength and the cash flow stream that we're going to be looking at going forward, the downside would be relatively protected. You know, this company has bought back a significant amount of its shares over time. I think you might see a big tender at that point for shares, or something very material happening on the buyback front in that scenario as well.

So I don't think they would be sitting on their hands. I think they would be deploying capital into reducing the share count in that scenario.

Andrew Walker

I completely agree. I could see you waking up to a press release that says, “A $250 million return of capital.” Whether that's through a tender—probably a tender, because I think with 4 shareholders owning almost 50%, I bet they'd be telling the company, “Hey, we want to get some liquidity.” Though a dividend gets you liquidity as well, so maybe I'm crazy.

A $250 million return of capital, a new management team, going after royalties to maximize use of the NOLs, and just cash flowing off Yupelri going forward—I think that would probably be the downside. But given everything we've talked about here, I hope we're not waking up to that scenario.

Andy, we've covered most of the stuff I wanted to talk about, I think. Is there anything else on the Theravance situation that you think we should be talking about, or that listeners should be thinking about?

Andy Summers

Well, look, I think in closing I would just say that this is an asymmetric setup. I think your downside is relatively protected. I think the upside case is probably north of $20; between $20 and $22 could be a fair range of value here. So we're talking maybe 40% to 50% upside, with limited downside.

I think the likelihood of something happening is very high for the reasons we discussed. So I think, for all those reasons, this is a position that I have in my fund.

Andrew Walker

Ditto, ditto, ditto, ditto. Let me end by putting you on the spot. I believe the company is scheduled to report earnings on May 7 or May 8. I think it's clear—I’d be shocked if we didn't have results then.

But if I set the over-under and gave you the options of announcing a deal before earnings, at the earnings release, or after earnings, which of those 3 options would you take?

Andy Summers

I would say there's a 90% chance that it's before.

Andrew Walker

Okay, so even into April, you think it could be that fast?

Andy Summers

It's funny. I'm on 2 corporate boards, Andrew, and I know how heavily scrutinized these press releases are before they get sent out. For them to craft that press release the way they did, I just believe that something is going to happen soon—very soon.

Andrew Walker

I'm on 0 corporate boards, so I'm just a guy sitting in a closet-size office recording a podcast, but I kind of agree with you. All I do is read these press release filings every day. When you say, “Hey, they've been working for 15 months and they're speeding up,” I think it happens fast.

At the same time, earnings is 7 weeks away at this point, right? So saying something happens before then is really damn fast, but I think I agree with you.

Andy Summers

Well, look, we live in a world where there's a lot of geopolitical chaos, right? That could certainly slow things down. It wouldn't be unusual for a management team to pause given the uncertainty in the world.

But absent that happening, there's no reason why this shouldn't be announced before the earnings date.

Andrew Walker

I hear you, but one of the things—I mean, biotech trades with enormous volatility relative to the markets for some reason, even though it should allegedly be one of the most economically resistant, economically insensitive sectors. They did announce this deal on March 3, when we were not at war with Iran.

But when you've got a partnered product that is growing and has about a decade of life left, it's pretty easy to model. It would just be shocking to me, with this board and this company, if they paused for any reason. It just doesn't seem like anything should be changing here.

Andy Summers

I agree, but we live in a chaotic world, so who knows?

Andrew Walker

Well, Andy Summers, look, I'm going to include a link to Andy's Twitter account, which I just found. Now I can follow all of your stuff. I was actually trolling it for some other stocks you'd been tweeting about and looking around, poking for value there.

This has been great. The next time you find a big royalty company that you're interested in, you're going to have to, at minimum, send me a message and let me know, because I love these things, too. At maximum, we'll have you back on to talk about this or something else.

But Andy Summers—link to his Twitter in the profile, and we'll go from there.

Andy Summers

Thanks, Andrew.

A quick disclaimer: Nothing on this podcast should be considered investment advice. Guests or the host may have positions in any of the stocks mentioned during this podcast. Please do your own work and consult a financial advisor. Thanks.