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All-In · · 90 分钟

AI 行业能否自我监管?Stripe 欲收购 PayPal,中国正在追赶,纽约禁建数据中心

Chamath PalihapitiyaJason CalacanisDavid SacksDavid Friedberg

YouTube
TL;DR
  • Demis Hassabis 提出的 FINRA 式自律监管组织,成为小组讨论中监管 AI 的“最不坏”答案。 这一由行业出资、联邦监督的机构将在模型发布前 30 天接收前沿模型,每季度更新风险测试,初期自愿参与。Sacks 只有在加入 5 项护栏后才支持该方案,包括代表初创公司和开源社区、限定灾难性风险范围以及不另设监管机构,否则替代方案可能变成“AI 车管所”。

  • 真正的监管争夺在于,SRO 究竟能防止监管俘获,还是仅仅成为 Anthropic 收紧管控的起手价。 Sacks 指责 Anthropic 鼓励各州逐步收紧规则,并认为一旦让步,政府就会“一次又一次地回来要求更多”;Chamath 也警告,资本充足的 incumbents 可能“把梯子收走”。Sacks 表示,这套方案必须替代新增监管;如果被视为行业底线,还要争取联邦优先权。

  • 据报道,一份由 Stripe 主导、价值 530 亿美元的 PayPal 收购要约,可能组装出 Visa 和 Mastercard 真正的挑战者。 讨论中的结构由 Stripe、Advent 以及可能加入的 Block 组成,对应 PayPal 每股约 60 美元;Chamath 预计最终成交价还会在此基础上上涨 10-15%。战略奖品不是 PayPal 老旧的界面,而是其约 4.39 亿个消费者账户,与 Stripe 的商户、Braintree、Venmo、Cash App 及稳定币基础设施连接起来——这将是“向 Visa 和 MasterCard 船头开火”(“a shot across the bow for Visa and MasterCard”)。

  • PayPal 可能开启一轮更广泛的收购周期,让 AI 原生操盘手重新激活被忽视的互联网老资产。 Friedberg 将这笔竞购与 Ryan Cohen 竞购 eBay、Bending Spoons 打包收购 Evernote、Vimeo 等 Web 2.0 资产联系起来:成熟、缺乏创始人掌舵的公司,可以由专业操盘手削减成本、自动化并重建。按照他刻意粗俗的说法,这将是一波“疲软的数字业务”靠“资本的蓝色小药丸”复活。

  • Apple 的商业秘密诉讼与 xAI 的 Grok Build 数据泄露,暴露了 AI 人才和专有数据周边的两种不同风险。 Apple 指控前员工带走“实际部件”并访问内部存储,而 OpenAI 在一年至两年内招募了超过 400 名 Apple 员工;Chamath 和 Sacks 暂不下判断,但给出一条绝对规则:只能带走“脑子里的东西”。与此同时,据报道 Grok Build 上传了完整代码仓库,尽管此前作出相反保证,进一步印证了 Chamath 的警告:零数据留存承诺也无法消除“到处都是后门”。

  • Token 经济学正从工程选择变成财报问题,而不再只是技术决策。 Chamath 提到,Lovable 每百万个 token 的价格为 56 美元,而中国模型为 0.50 美元;Ramp 则表示,客户的 token 支出一年内增长了 21 倍。Sacks 警告,如果工程师默认使用前沿模型来处理更便宜模型就能完成的工作,上市公司 CFO 最终可能因为 AI 运营支出变成“烧钱熔炉”而错过一个季度。

  • 对美国 AI 增长构成硬约束的不是模型需求,而是电力。 Chamath 预计,到 2050 年美国将面临相当于当前 2.5 个加州用电量的能源缺口;他提到一场寻求 7-8 GW 电力的 PGM 拍卖,最终只吸引了约 156 MW 的供给,并称约 40% 的规划项目正在被叫停或搁置。因此,纽约的超大规模数据中心暂停令会抬高当前可接入电网站点的价值,并把部署规则推向“GPU 追逐能源”。

  • 节目最后落脚于一个已经出现的 AI 生物技术成果,而不是一场假设中的灾难。 Friedberg 介绍了一种借助 AlphaFold 设计的酶,经过 5 轮定向进化,在受测蛋白质中去除了 52-97% 的衰老相关分子 CML,并从 70 岁以上人士捐赠的皮肤中去除 55%,据称将测得的皮肤年龄降至 31 岁。递送方式仍未解决,但 Chamath 立即看到了第一个市场:“涂在脸上,当面霜。游戏结束。”

摘要 · 为研究而整理的核心内容

1. 前沿 AI 的 FINRA 获支持,成为“最不坏”选项

  • Jason 介绍了 Demis Hassabis 提出的美国主导型 SRO:由行业出资,由独立技术专家组成,并接受联邦监督。前沿实验室需要在模型发布前 30 天提交模型,基准测试每季度更新,参与初期为自愿,未来可能转为强制;如果出现严重风险,该机构还可以协调放缓发布节奏。

  • Friedberg 认为,类比 FINRA 和美国全国期货协会(NFA)是成立的,因为市场参与者需要得到共同风险的保护,但不能把技术冻结在成文法里。他表示,加州尝试制定的规则一年后已经无法对应这项技术;SRO 则可以随着网络、生物、武器和操纵风险的变化,更新测试、评估者和专业能力。

  • Friedberg 强调的关键区别是“联邦政府监督,但不控制”。现有金融 SRO 最终由国会委员会监督,但规则由从业者制定和执行;在他看来,这比新设一个监管机构更快,也更具技术可信度。

  • Jason 总结称,Elon Musk、Sam Altman、Jack Clark、Sundar Pichai、Satya Nadella、Jack Dorsey 以及 Collison 兄弟都支持这一方向。Friedberg 认为,这个联盟的共识是监管检查点终将到来,而自律监管提供了一种可操作的实现方式。

2. Sacks 提出 5 项条件,才接受这个次坏方案

  • Sacks 表示,SRO 必须代表初创公司和开源社区,而不能只代表 3 家最大的实验室。他提出的联盟应足够广泛,纳入 Jensen Huang、Elon Musk、Mark Zuckerberg 和 Mira Murati;后者的 Thinking Machines 平台被描述为基于开源的开放权重模型平台。利益多元化,是防止监管俘获的屏障。

  • 审查对象只能是相对现有前沿实现真正跃迁的模型。拦住劣质或渐进式模型,并不会相应降低灾难性风险,反而会给 incumbents 提供一个轻易拖住小型竞争对手的工具。

  • SRO 的权限应止于灾难性网络风险和 CBRN 风险,即化学、生物、放射性和核风险。Sacks 明确排除了虚假信息、冒犯性言论及其他言论问题:“不能变成言论监管机构。”同时,机构应先在自愿参与下证明自身有效,再获得法律强制力。

  • 他提出的第 5 项、也是决定性条件是替代关系:不能在另一个联邦监管机构之上再叠加一个 SRO。“AI 版 FAA”可能把模型发布从几个月拖成几年;Sacks 指出,新飞机型号认证需要 5-9 年,改型认证需要 3-5 年。在 FAA 或“AI 车管所”与一个严格限定边界的 SRO 之间,他选择后者。

3. 监管俘获仍是未解威胁

  • Chamath 预计,“巨额资金洪流”会推动监管为两党阵营的 incumbents 服务。快速建立可信的行业规则,可以堵住通向双寡头的出口;与此同时,司法部、商务部和联邦监督仍能阻止真正的“狂野西部”。

  • Sacks 表示,即便 FINRA 最终也要向 SEC 汇报,因此 AI SRO 的政府归属必然引发政治争斗。软件行业从未拥有专门监管机构;照搬这一结构,可能制造监管压力和监管俘获,即使最初的权限看起来很窄。

  • 他更大的指控是,Anthropic 正在执行一套由恐惧驱动的监管俘获策略。Sacks 称 Anthropic 的估值已经达到 1 万亿美元,并引用 Gavin Baker 对其 IPO 后估值 3 万亿美元的预测;他还提到 Politico 报道的“比谁更严”现象,即加州 SB 53 等规则成为各州逐步收紧立法的模板。

  • 政府监管棘轮效应是他警告的核心:当一家公司向官员要求更多权力时,很少有人会回答“我们没有资格”。Sacks 表示,SRO 只有在行业把它当作底线、争取联邦优先权并抵制额外要求时才可能奏效;如果把它“免费送出”,它就只是第一轮报价。

4. Stripe 竞购 PayPal,本质是攻击卡网络经济学

  • 节目播出时媒体报道仍不一致,但 Jason 表示,Stripe 和 Advent 正以约 530 亿美元、即每股 60 美元的价格报价收购 PayPal,Block 则通过约 170 亿美元股权参与。市场预期价格更接近 70 美元;Chamath 预计最终成交价会比初始报价再高 10-15%。

  • 小组的战略判断是,Stripe 的商户关系与 PayPal 的消费者基础结合后,可以形成更完整的支付通道,挑战 Visa 和 Mastercard。Block 则能补上销售点基础设施和 Cash App。

  • 资产拼图支持这一判断:PayPal 带来 4.39 亿个消费者账户、Venmo、Braintree 和 PYUSD;Stripe 带来商户 API、2025 年以 10 亿美元收购的 Bridge,以及约 2 万亿美元年交易额;Block 带来销售点基础设施和 Cash App。PayPal 自身的年交易额约为 1.7 万亿美元。

  • Sacks 担心,商户关系与消费者关系合并,并不会自动让消费者选择新的支付方式。Chamath 则把决策权转向商户:通过更便宜的内部通道给消费者提供 3-5% 的折扣,Stripe 或其他参与商家就会偏向这一选项,因为这能让它们多留存 2-4% 的利润。

5. 市场定义决定这笔交易是垄断还是挑战者

  • 反垄断争论完全取决于市场如何界定。如果市场被定义为商户支付 API,那么 Stripe 与 PayPal 旗下 Braintree 的合并看起来是在集中市场;如果市场被定义为支付网络,这笔交易则是在 Visa-Mastercard 双寡头之外创造一个新竞争者。Chamath 说:“这就是游戏规则。”

  • PayPal 的吸引力部分来自它的困境。Sacks 称这套使用了 25 年的交互模式已经“过时”,增长只有约 7%;他指出,PayPal 的估值已从其所称的 3220 亿美元高点,跌至要约发布前约 300亿-400亿美元。单靠提效无法解决产品现代化和重新确立愿景的需求。

  • Chamath 的回答更简单:“我认为他们买的是账户。”Stripe 已经拥有 PayPal 缺少的商户关系,而 PayPal 拥有 Stripe 缺少的消费者关系;即便原有 PayPal 界面逐步退役,更多“on-us”交易仍可以绕开卡网络费用。

  • Sacks 将 PayPal 的停滞追溯到 eBay 在 2002 年收购后清除了 PayPal 的创始基因,代之以企业化、咨询主导的思维。他更愿意使用“PayPal 流散者”而不是“PayPal Mafia”这个说法:“我们的故土被占领,他们烧了我们的神殿,然后把所有人赶了出去。”

6. AI 原生操盘手或将把老旧互联网公司变成新型收购品类

  • Friedberg 将 PayPal 与 Ryan Cohen 竞购 eBay 联系起来:现代操盘手审视成熟、缺乏创始人掌舵的数字业务时,可以立刻看到闲置网络、臃肿成本和尚未落地的 AI。资本提供者的难题是找到能够重建产品的操盘手,而不是去雇“某个麦肯锡顾问”。Friedberg 表示,Cohen 已通过 Chewy 和 GameStop 证明了自己的能力,但也承认对后者的评价存在争议。

  • 他预计,“一波巨型交易”会让“疲软的数字业务”在“资本的蓝色小药丸和正确操盘手”帮助下复苏。已有案例包括 Josh Kushner 对会计师事务所的整合收购,以及 General Catalyst 的类似尝试;两者都在用收购资本为传统服务业注入 AI。

  • Bending Spoons 是一个运营样本。Jason 列出了 AOL 和 Vimeo,各自交易价格为 14 亿美元,此外还有 WeTransfer、Eventbrite、Brightcove 和 Evernote;Friedberg 介绍称,这支来自米兰的团队会诊断超支、投入不足、产品和营销问题,再通过杠杆让老 Web 2.0 资产产生现金。Jason 说,他听闻这家公司使用的是年轻、AI 优先的管理者。

  • Jason 将宏观背景概括为 Lina Khan 任期结束及 Trump 当选后,M&A 正在回归。他提到 Uber 以 150 亿美元收购 Delivery Hero,称这笔交易大约意味着 10% 的稀释,却换来预计 24% 的收入增长,“或者类似这么夸张的数字”;他还表示,收购活动加上 SpaceX 分配收益,正在重新激发 LP 和家族办公室对风险投资敞口的兴趣。

7. Apple 诉讼将人才流动推向商业秘密边界测试

  • Apple 于 7 月 10 日提交的 41 页诉状称,OpenAI 在开发消费硬件时使用了被窃取的商业秘密。前 iPhone 设计副总裁 Tang Tan 据称要求候选人带“实际部件”参加面试展示;前工程师 Chang Liu 则据报道发短信称:“笑死。我发现自己可以访问网络存储。太好笑了。”

  • Jason 强调了规模:OpenAI 在一年至两年内招募了超过 400 名 Apple 员工;双方关系也因此受损,因为 ChatGPT 原本预计会成为 iPhone 的默认 AI。Chamath 仍拒绝在裁决前传播八卦,只指出 Apple 罕见地选择诉讼,说明其愤怒程度很高。

  • 这场争议在事实尚未厘清的情况下,仍得出一条适用范围明确的规则:员工可以在加州跳槽,也可以带走积累的知识,但不能带走实体部件、硬盘、文件或资料。Sacks 的表述是绝对的:“你能带到新工作的唯一东西,就是脑子里的东西。仅此而已。”

8. Grok Build 说明为何零留存不是信任边界

  • 据报道,由 Grok 4.5 驱动的 xAI Grok Build 将开发者的完整代码仓库发送到了 SpaceX 云服务器,尽管此前保证不会传输代码库数据。上传内容可能包括密码、API 密钥和变更日志;隐私设置未能生效,上传功能于 7 月 13 日由服务器端关闭,Elon Musk 表示此前上传的数据已经删除。

  • Chamath 的结论超出了这一个明显的实施错误:“AI 隐私非常脆弱,也非常不牢靠。”即便供应商真诚提供零数据留存,也无法保证不存在未知的泄露路径;打开 ZDR 开关,并不意味着“事情就没问题了”。

  • 他主张在企业与模型之间增加一层独立中间层,同时披露 8090 正通过其软件工厂为大型企业提供这类服务。其作用是在一个“分层生态”中控制数据暴露,而不是信任每一家供应商的具体实现。

  • Sacks 引用了 “Sacha” 的一篇博客,标题为《信息逆向悖论》。这篇文章延伸了 Alex Karp 关于企业希望控制算力、模型、权重、数据和 alpha 的观点,并建议企业在私有环境中进行评估、在租户内部运行专有学习闭环、将编排层解耦,同时明确保留对自身输出进行微调的权利。

9. Token 支出正从工程预算走向财报电话会

  • Chamath 引用的价格表显示,Lovable 每 100 万个 token 的价格约为 56 美元,Bolt 约为 26 美元——他给 Claude 4.8 的报价也是这一数字;Grok 和 Zuck 的模型约为 1.50 美元,Elon 的模型约为 1 美元,中国模型为 0.50 美元。他质疑的是高价与专有知识外泄风险的叠加。

  • Ramp CEO Eric Gleiman 表示,客户的 token 支出一年内增长了 21 倍,并推出 Token Spend Management,同时面向 Ramp 客户和非 Ramp 客户。AI 供应商实际上开出了一个没有上限的“账单”,而 CFO 很难看见或控制员工分散产生的消费。

  • Sacks 将这条 21 倍增长曲线直接连接到财报:一家公司最终可能因为 token 运营支出失去控制而错过一个季度。工程师自然会选择“最新、最强的模型”,但并不负责衡量 ROI;Chamath 表示,CFO 必须判断 95% 的工作是否可以交给比前沿模型低一档的模型完成,成本可能只有前者的 1/100。

  • Jason 的反方观点是,廉价的本地推理可能让 Apple 成为“强力买入标的”。他提到 M7 Ultra 配置最高可搭载 1.5 TB 内存,并设想 90-99% 的工作负载都在一台 4,000-5,000 美元的 Mac Studio 上运行;Sacks 和 Chamath 随即否定了他关于初代 iPhone 曾被广泛嘲笑的说法。

10. AI 建设潮撞上严重电力短缺

  • Chamath 预计,到 2050 年,美国将缺少相当于当前加州用电量 2.5 倍的能源。在一场覆盖 Pennsylvania、New Jersey、Maryland 等州的 PGM 拍卖中,他表示系统寻求约 7-8 GW 的电力,却只收到约 156 MW 的供给。

  • 在他的数据中心投资组合中,能够证明今天就有可用电力的站点,可以获得极高的前端价格,因为约 40% 的潜在项目正在被搁置或叫停。即便模型和客户都已存在,这一约束仍可能让药物发现、癌症诊断、医疗和法律服务的需求无法得到满足。

  • 表后发电可以通过现场发电,绕过等待公用事业公司并网的过程。Chamath 介绍了 Elon Musk 如何在 Memphis 为 Colossus 使用移动涡轮机,同时应对清洁空气许可要求;他还提到 Bloom Energy 是大规模现场安装的另一条路径。即使设施自带电力,监管复杂性仍然存在。

  • Sunrun 和与 NVIDIA 合作的 Span 被提及为正在建设分布式住宅数据中心集群的公司。结合本地模型、太阳能和电池,这意味着算力可能向边缘分散;但 Jason 给出的近期规则更简单:“GPU 追逐能源。”

11. 纽约暂停令令有电站点更稀缺,并把投资推向其他地区

  • Governor Kathy Hochul 宣布了她所称的全美首个州级超大规模数据中心暂停令,理由包括化石燃料排放、土地置换、更高的公用事业账单、水资源枯竭和噪音。Sacks 逐一反驳这些前提,认为表后电力可以避免数据中心与居民电力用户竞争。

  • 他的反驳是,数据中心属于土地利用效率非常高的设施,噪音可控,可以使用闭环水系统,并带来可观的建设、运营和税收收入。他引用一项研究称,典型数据中心的用水量约相当于 2.5 家 In-N-Out Burger;Chamath 则回忆说,地方税收暴增曾让教师获得 30,000-40,000 美元的奖金。

  • Sacks 认为,暂停令可能是一种暂时的政治杠杆:先暂停建设,等未来政府要求设立监管机构、实施言论控制及其他条件。即便暂停令在 2.5-3 年后解除,他估计项目重启仍可能导致 New York 至少 5 年内都不会再有另一座运营中的数据中心。

  • 出口管制则通过限制盟友国家部署芯片,进一步加剧国内约束。Chamath 原本预计中东会出现更多数据中心建设,但实际看到的是亚洲,尤其是 Australia 的快速增长;他指出,凭借地理位置和能源供应,中东可以在 200 毫秒以内服务约 40 亿人。

12. 小组认为,道德恐慌将先于可量化灾难到来

  • 节目播放的一段 Rupert Darwall 片段将反转基因情绪作为类比:这种情绪在 Russia Today 于 2010 年进入美国后上升,又在该媒体失去分发渠道后回落。他没有声称已经证明因果关系,但担心 NGO 资金、媒体重复报道和社交传播同样可能反映外国势力对反数据中心行动的兴趣。

  • Sacks 进一步引用了 OpenAI 的一篇文章,标题为《与 PRC 有关联的影响行动正在瞄准美国 AI 争论》。Chamath 表示,如果 China 能够推动 Anthropic“把梯子收走”、消灭开源,让美国用户为每个 token 支付高出 50-100 倍的价格,那么即使技术上仅够用的外国竞争者,也可能弥补技术劣势。Sacks 同意,外国政府影响美国政策的动机显而易见。

  • Sacks 的紧迫感来自 Kimi K3,他称其“非常、非常接近前沿”:美国可能“领先 China 几个月,仅此而已”。与此同时,Sacks 表示,此前提出的 10^25 FLOPS 危险阈值已经被每一个 AI 模型跨越,却没有出现预言中的灾难;Dario Amodei 关于 50% 的入门级知识工作可能在 1-5 年内消失的警告,也仍未得到证明。

  • Friedberg 更倾向于“监测”而不是恐慌——随着证据积累,观察自动驾驶对就业的影响、黑客能力和岗位损失。Sacks 将 Anthropic 所谓的商业策略概括为 3 步:“把自己包装成一家安全的 AI 公司。第二,禁止不安全的 AI。第三,获利。”

13. AlphaFold 协助设计出可清除衰老副产物的酶

  • Friedberg 将讨论从 Yamanaka 因子细胞 rejuvenation 转向细胞外基质。随着年龄增长,糖和脂肪会通过糖基化与蛋白质结合,改变胶原蛋白等结构,限制修复并引发炎症;CML 是一种主要的晚期糖基化终产物,他说目前没有任何东西能将其分解。

  • 节目中提到的 Calico 与 Reval Pharma 合作,使用 AlphaFold 找到一种能够结合 CML 并开始降解它的细菌蛋白。研究人员随后修改其 DNA,生成数百乃至数千个变体,筛选活性,并将这一轮定向进化过程重复了 5 次。

  • 由此得到的酶据称从酪蛋白、胶原蛋白、视网膜蛋白和血红蛋白中去除了 52-97% 的 CML,其中多个位点的去除率超过 90%。在 70 岁以上人士捐赠的皮肤样本中,该酶去除了 55% 的 CML;Friedberg 将其描述为把组织测得的年龄逆转到 31 岁水平。

  • 尚未解决的问题是递送方式:面霜、注射、补充剂,还是让人体在体内产生这种酶的 RNA 注射。Chamath 预计,化妆品会先于关节或全身治疗落地,并称一款成功的面霜可能对应 1 万亿美元、几分钟后又改口为 2 万亿美元的市场;Friedberg 更大的重点是,这是“用 AlphaFold 发现这个东西,再把它进化出来”。

Jason Calacanis

All right, everybody, welcome back to the world's greatest podcast, the number one podcast, your favorite podcast, the All-In Podcast. I'm Jason Calacanis, the world's greatest moderator. With me, of course, Chamath Palihapitiya of-

Chamath Palihapitiya

The great-great-great-great-great-great-great-great-grandchild of Jason was a hooker and a—

Jason Calacanis

You saw that? From Fred?

Chamath Palihapitiya

And a prisoner. And a purse snatcher.

David Friedberg

Purse snatcher.

Jason Calacanis

This comes from a history of France, some History Channel—

David Friedberg

The Potato Thieves.

Jason Calacanis

—said they let you out of—This was the deal in 1719, Sacks. If you were a prisoner in Paris, you were offered your freedom on the condition that you marry a prostitute and move to the great state of Louisiana. What are you saying, Sacks? Are you taking the deal?

Chamath Palihapitiya

It explains a certain one of your proclivities, J-Cal.

Jason Calacanis

I thought you were asking me to see if they would extend the rule for you.

Chamath Palihapitiya

No, I'm saying that your great-great-great-great-great-great-grandmother was a hooker.

Jason Calacanis

I'm not French, I'm Greek.

Chamath Palihapitiya

That's what I'm saying very explicitly. She was a hooker.

Jason Calacanis

We never spent time in a prison. Also, of course, David Friedberg is here. How are you doing, brother?

David Friedberg

Living the dream.

Jason Calacanis

Yeah?

David Friedberg

It's good to be back. Missed you guys last week. How was Brad? How did he fill in?

Jason Calacanis

Brad was great. Yeah, he was great.

David Friedberg

Trump account victory lap?

Jason Calacanis

He had a little victory lap. We played “Chariots of Fire” and, “How was your special time at blank?” and “Your time next week at blank?”

David Friedberg

Thanks for having me on your show, J-Cal.

1. The AI Regulation Proposal

Jason Calacanis

All right, we’ve got a full docket today. Lots of stories. Let’s start with DeepMind’s Demis Hassabis, who just dropped an AI regulation proposal, and it’s pretty popular with the boys. In an X article, Demis called for a U.S.-led international AI standards body. It is modeled after FINRA, the Financial Industry Regulatory Authority. That’s a self-regulatory body, and this would be federally overseen but industry-funded and run by independent technological experts.

Frontier labs would submit their models 30 days before release. It would be voluntary initially, then mandatory at some point. The models would be assessed for risk to cybersecurity, national security, biological threats, and other high-risk domains. Benchmarks would be updated quarterly, and the body could coordinate a slowdown in development if the situation demanded it. I guess that would be if there was a cyber risk, et cetera.

It looks like, on the positive side, we have Elon, who said it was thoughtful; Sam at OpenAI; Jack Clark at Anthropic; Sundar; Satya; Jack Dorsey from Block; and the Collison brothers. Friedberg, your thoughts on—

Chamath Palihapitiya

Well, way to really put in the effort today. Go ahead, Jason. Good so far.

Jason Calacanis

Just pass it to me, J-Cal. I’ll take care of it.

David Friedberg

France at 6:00.

Chamath Palihapitiya

Go ahead.

David Friedberg

Let me do my show. Go.

Jason Calacanis

What do you want me to do? Oh, my God, what an incredible topic.

David Friedberg

Give me the mic.

Jason Calacanis

All right, here, let me do it. You want me to do it, right?

David Friedberg

Some of us actually care about this topic. Let’s go.

Jason Calacanis

Here’s a clip of me calling it on the All-In Podcast first. The whole industry is gonna need to be regulated, and I think the industry needs to regulate itself. That’s the key to this. We need to have a set of tests that Google, Microsoft, and Amazon all agree to. Elon says, “Hey, these are the things we should test,” and they should self-certify each model before asking the government, which doesn’t understand the models, to certify them.

The industry should have an industry certification, like they do for countless other things. I’ve talked about the MPAA and the video game industry. We should just self-certify. It’s the simplest thing in the world to do, and then we could release the models ourselves without the government getting involved. Friedberg, would you like to congratulate me on nailing it again?

Chamath Palihapitiya

Well, first of all, I thought that Demis’ proposal was really smart and thoughtful. Now that I know that you may have shared the same thought, I think we should just do something totally different.

Jason Calacanis

Can’t win. I can’t win, Sacks. Even when I nail it, I hit a half-court shot, and Chamath’s like, “Move the net. Move the net.”

David Friedberg

No.

David Friedberg

I think it’s worth putting a little definition around this proposal, which is to form an SRO, or self-regulatory organization, because they’re not purely independent. SROs like FINRA and the National Futures Association exist in the financial markets, and they were created to allow the financial institutions to set their regulatory rules—how they check each other and how they make sure that everyone is being safe—because they’re obviously all trading risk with one another.

The industry doesn’t want to have exposure, and they certainly don’t want to have things slowed down, because that would make the markets inefficient. So the analogy with AI is pretty appropriate here: There are many players in the industry, they are all trying to progress AI technology, and no one wants to have a single regulatory body that comes in from the government or outside and says, “Here are the tests you guys have to pass with your models in order for them to be appropriate.”

As we saw in California, when California tried to pass AI legislation—I think it was about a year or a year and a half ago—none of what they wrote even made sense at the time. But fast-forward a year, and none of those rules and requirements actually map to the technology of the day.

So the purpose of an SRO like FINRA and the NFA is that they can adjust how tests are being run, who is actually running the tests, and make sure the right experts are involved in doing this—independent experts, that is—to do the testing, with federal government oversight but not control. In the case of FINRA and the NFA, they report up ultimately to a Senate committee and a House committee, which gives those committees oversight of the governing bodies that are supposed to be doing the work to make sure that they’re doing their jobs.

So the SRO concept would be that experts could be brought in from the industry who know how to assess models for things like cyber risk, bio risk, weapons risk, social manipulation, et cetera, et cetera. That independent body can get voted on and can get changed over time. Because they actually have expertise in running software evals and running tests like this, they can operate at a faster pace than setting up a new government agency.

It’s kind of a very elegant solution, and I think it’s why everyone, to your point, J-Cal—I’ll say this, right—the industry recognizes that there needs to be some degree of oversight and checkpoints here. I think that this could actually solve that problem. That’s why everyone is climbing on board with it, because it doesn’t actually hand stuff over to the government. It says, “Hey, we’re gonna get the right people to take a look at these things,” and the government is gonna have oversight ultimately.

Jason Calacanis

Did Anthropic and OpenAI have a point of view?

David Friedberg

They both signed up to it. I don’t think Dario directly, but Dario’s president gave his thumbs-up, and then I think Sam gave his thumbs-up.

Jason Calacanis

Which means they’re on board. Sacks, is this the best of the possibilities in your mind? Is the industry regulating itself after they’ve now provoked governments around the world—

David Sacks

Right.

Jason Calacanis

—to be so concerned about this issue?

David Sacks

Yeah, and I talked to Demis about this. This may surprise people, but I told him that I could potentially get on board with this, speaking just for myself, not on behalf of anyone in the government. I thought that an SRO, again, a self-regulatory approach, would be infinitely better than creating a new government agency that I think would rapidly become a DMV for AI.

Jason Calacanis

Hmm.

David Sacks

Dario calls it an FAA for AI. The government does not have the expertise to evaluate AI models. The criteria are changing too rapidly. You’re gonna very rapidly end up with a queue where all the models would be waiting to get tested. It would start with a month-long delay, end up being many months, and we would just lose the AI race.

So I think an SRO approach would be infinitely better than that if it was done right. I outlined for Demis five criteria or conditions that I thought were really important in order to make this work, and if I could, I’ll just—

Jason Calacanis

Yeah, walk through it.

David Sacks

—run through them.

Jason Calacanis

Please.

David Sacks

All right. Number 1, I think the SRO has to have broad representation from within the AI industry. It has to include startups and open source. It can’t just be the 3 biggest labs, you know? It can’t just be—

Jason Calacanis

Google.

David Sacks

Yeah, exactly, and that’s precisely to avoid the problem of regulatory capture, right? If you have a diverse enough group of interests being represented, it’s much harder for this to turn into regulatory capture. So, for example, I think if you had Jensen, Elon, Zuck, and maybe Mira, because she just launched a very interesting—

Jason Calacanis

Open-weight model.

David Sacks

platform that's based on open source.

Jason Calacanis

Thinking Machines, yeah.

David Sacks

Yes, exactly. I think that would address the regulatory-capture problem to a large degree. So, for example, if you had Jensen, Elon, Zuck, and maybe Mira, because she just launched a very interesting open-weight model platform, that's based on open source, I think that would address the regulatory-capture problem.

So that's number 1. Number 2 is that I think this body should only be reviewing frontier models, meaning the true frontier—the models that really represent an advance in the state of the art of artificial intelligence. Models below this level should not be held up from getting to market.

I do think that's a big risk under regulation: that the leaders in the market use this as a way to tie up lesser models. If a model is not at the frontier, why hold it up? That's number 2.

Jason Calacanis

So they have to be maybe in the top 10 performers, top 20 performers, on the benchmark tests?

David Sacks

Well, no. I think when they benchmark on key dimensions of intelligence, they have to represent an increase above—

Jason Calacanis

Got it.

David Sacks

—where the current state of the art is. If it's not a step change, then how are you dealing with some new incremental risk? This is all about dealing with some sort of incremental catastrophic risk that could be introduced by a new step change in intelligence.

That brings me to number 3, which is that I think this body should be dealing with catastrophic risks only. To my knowledge, those right now are cyber and CBRN, meaning chemical, biological, radiological, and nuclear.

It should not cover things like disinformation or microaggressions. This should not become a speech regulator, or just address things that seem trivial. The only reason to have this is for truly catastrophic risks. That's number 3.

Number 4, and Demis Hassabis mentioned this in his post, is that I think it should be voluntary first. This new organization should prove that it works before it gets legally enshrined and becomes mandatory.

Number 5 is that this should be a substitute for a new regulatory agency. If it's just additive, then it defeats the purpose, and there's no real reason to support it. This has to be a substitute, not an addition to a bunch of new regulatory structures.

I think if you did those 5 things, this becomes much more palatable. Demis said—I mean, he didn't put all these points in his blog post, but he did say to me that he thought those were good ideas. If those points were adopted, this is something that we could potentially get on board with.

That doesn't mean I don't still have concerns. I'm quite concerned, for example, that Dario Amodei has expressed support for this. However, I think this is just an opening bid for Anthropic. They'll take this—thank you very much, this is more regulation than we have today—but that won't be the end of it.

This will just be the stepping stone to get what Dario has now called for many times, which is the FAA for AI. If I could, let me just, as a final point, explain what the FAA does, because people need to understand that FAA for AI sounds really nice, but it's actually a really extreme proposal.

What the FAA does, among other things, is approve new airplane designs. Specifically, it requires what's called a type certification for any new aircraft design or major changes. For an entirely new aircraft design, it takes 5 to 9 years to get the certification.

If you merely want to amend a certificate for major changes—and I'm not even sure how major the changes need to be—it takes 3 to 5 years. The Boeing 737 MAX, for example, took about 5 years.

This is permission-based regulation. There's no approval, no flying commercially. It's safety first. That might make sense in the case of preventing plane crashes, but when you're talking about AI models, you're talking about replacing a system that is releasing new versions every couple of months with one that is potentially fully under the control of the government, fully government-approved.

Everything has to be certified, and you could expect the timeline to go from months to years. I think we'll simply lose the AI race if that happens, because China isn't going to abide by those rules.

To sum up, if my choices are between FAA for AI or what I would call the DMV for AI, I would much rather go for Demis Hassabis's SRO for AI—the self-regulatory approach. But we really have to keep it honest and pure because otherwise it'll just be the opening bid in a coming new wave of regulation, and it will be the vehicle for massive regulatory capture and—

Chamath Palihapitiya

And it can't, to your point, restrict open source.

David Sacks

—and slow down innovation. Yeah.

Chamath Palihapitiya

It can't restrict open source. I think that's so important because all of these other efforts require money that you have to spend, which is always where regulatory capture happens, and you have to enable startups and open source to compete effectively.

Jason Calacanis

Chamath, any thoughts on this new self-governing body?

Chamath Palihapitiya

I think it's really important, and I hope it happens quickly. The thing we have to keep in mind is that there's going to be a torrent of money that's going to try to influence both sides of the political aisle to regulate this in a way that creates some form of regulatory capture. We just don't know what that form will take.

The faster we avoid that off-ramp by actually establishing a set of rules and superseding the need for federal oversight, the better. At the end of the day, you still have federal oversight in some ways, because you still have Commerce that plays a huge role in these standards, and you still have the DOJ. So it's not as if it's going to be the Wild West.

What it prevents is a handful of actors using their balance sheets and their capital to essentially pull the ladder up. I think if that happens, we're in a really bad place. Demis's proposal makes a ton of sense, and we should just get on with it.

Jason Calacanis

All right.

David Sacks

Well, yes, provided that we make sure it's pure. In my view, there are 5 conditions, but we do have to make sure it's pure.

Even in the FINRA example—the analogy that Demis used was that we should set this up in the same way that FINRA is set up—FINRA ultimately reports to the government. It reports to the SEC. If we're going to set up this new SRO, where is it going to report in the government? There's going to be a huge food fight over that, and it will then be subject to political pressure.

The software industry has never been regulated in that way. We do not have a dedicated regulator for software.

Chamath Palihapitiya

No, I think you're right. Those issues are important.

David Sacks

Yeah.

Chamath Palihapitiya

But my point is, Sacks, I'm just saying these things are never ideal. But if the choices are that we kill open source and pull the ladder up on the entire market so there's a duopoly, or there's this, I'd say this.

David Sacks

For sure. And that's—

Chamath Palihapitiya

Yeah.

David Sacks

—and that's the crux of my argument. It's definitely the lesser of 2 evils. I'm not sure those are the only 2 choices, but increasingly, there's no question that the pressure is coming to regulate AI more and more. Frankly, this all goes back to Anthropic's government-relations effort.

Chamath Palihapitiya

They poked the tiger. They poked the tiger.

David Sacks

Yeah. Well, it's more than that.

Chamath Palihapitiya

They're funding the fear of the tiger.

David Sacks

They're funding it. Yeah. I want to give an update on that, actually, because—

Chamath Palihapitiya

I would say they're poking the tiger of the American public getting really freaked out and then the government stepping in.

David Sacks

Totally.

Chamath Palihapitiya

Yeah.

David Sacks

Totally. There are a couple of data points on that, actually. I want to give a quick update.

2. The Anthropic Capture Strategy

In October of last year, I tweeted that Anthropic was running a sophisticated regulatory-capture strategy based on fearmongering, and everyone went crazy over this. This was a very hot take, or spicy take, at the time. Back then, people thought that I was beating up on a little startup.

Now I think everyone can see the truth, which is that this is not a little startup. They already have a trillion dollar market cap valuation. Gavin Baker thinks it'll be at 3 trillion after the IPO. This is actually one of the biggest of the big tech companies, and by pretty much every criterion, including revenue, they are the leading AI company.

People can see now that they have enormous resources, and they're putting those resources behind an effort to, as Chamath said, pull up the ladder. It's classic regulatory capture.

There was an article in Politico just the other day called “Inside Anthropic’s State-by-State Plan to Ratchet Up AI Rules.” It says, quote, “AI giant Anthropic is pursuing a strategy of one-upmanship that encourages states to impose increasingly tougher AI guardrails rather than align around a single set of regulations.”

The basic idea is that they get a set of regulations passed in 1 state, like California's SB 53, and that was then supposed to be the model, at least for all the blue states. But with each new state, they actually make the regulations more and more strict, more and more all-encompassing, so there's not actually a stable equilibrium.

What they're trying to do is drive each incremental state toward more and more regulation. This article explains that they're doing the opposite of trying to create what we wanted, which was a single national framework. They actually want the patchwork because they're using the pressure they're creating at the state level to impose more and more regulations.

And again, what I said last year was that Anthropic was principally responsible for the state regulatory frenzy that is damaging the startup ecosystem. Again, everyone went crazy at the time. I think now there's plenty of evidence showing that this is their agenda.

Jason Calacanis

And by the way, they're going to win that because states have great sovereignty rights. Like we're seeing with self-driving, the states are going to decide. It's not going to be a federal mandate. The states get to decide the nature of the U.S.—

And so they're going to win on that in a couple of states, right, Sacks? Just realistically.

David Sacks

Well, they have. They've won in a bunch of states. They've already won in California, Illinois, and New York. They're winning in all the blue states and maybe even some red states. But look, ultimately, the reason why Anthropic's arguments are finding purchase is because when you go to the government and say, "Please regulate me. You should have more power," there's hardly anyone in government—

Jason Calacanis

Yeah.

David Sacks

—who will ever say, "Oh, no, no, no. We're not qualified. We don't want the power."

Jason Calacanis

We're for less government.

David Sacks

Yeah. There are very few people who are principled that way, and most people in the government will say, "Thank you very much. What else can we take?" This is the mistake that I think a lot of people in the tech industry are making: They think that they can just buy off politicians or the political system by making concessions. No, that will just lead to a ratcheting up of the pressure. The government will be happy to take this and then come back for more and more and more until it's fully under government control.

So at some point, I think these companies are going to have to grow a spine and fight and decide where they're willing to draw a line. And if Demis's SRO is the line, if they're saying, "Okay, we think this is the right solution, and we're going to fight here, and this has to be it. In exchange for this, we need preemption, and we need other things written into law that make sure this is where the line is," then I think it can work. But I think if you're just offering it up for free, and all these companies are just going to say, "Oh, yeah, regulate. Give us the SRO," that will not be the end of it. That will just be the opening bid, and the government will come back to take more and more and more.

Jason Calacanis

All right, let's keep moving through the docket here. Stripe, which is still a private company, much to the chagrin of many of the shareholders, I think, now as they go into their second day.

David Sacks

On the SOT.

Jason Calacanis

On the—yes. I mean, I'm in a couple of funds that have large positions. Go public, boys. They are bidding $53 billion for your alma mater, David Sacks—PayPal—which is a public company. Stripe and the private equity fund Advent are jointly offering to acquire PayPal for about $60 a share, which is a small premium. Most people think it'll go for more like $70 a share. PayPal stock jumped on the news, obviously—

David Sacks

Were you able to get to the bottom of this? Was it just Stripe and Advent? Because then—

Jason Calacanis

No, we're about to get into it.

David Sacks

Somebody else reported that it was also Block.

Jason Calacanis

Yes. Block is coming in as well.

David Sacks

It's so confusing. Every other media source is all over the place on this.

Jason Calacanis

Yeah. No, I think it's because it was a breaking story, and maybe they were trying to keep it quiet.

David Sacks

It's a huge deal, though, if Block is a part of it versus if they're not, I think.

Jason Calacanis

Yes. Block, formerly known as Square, is Jack Dorsey's payment company, one of the few entrepreneurs to ever create 2 decacorns in our industry. They're contributing $17 billion in equity to the combined offer. How they chop up what's inside PayPal would be the big question. Obviously, they own a number of different brands, including Venmo in addition to PayPal. That might go really well with the—I'm just taking a guess here—with the Block assets.

Stripe owns Bridge, their stablecoin infrastructure company, which they acquired for $1 billion in 2025. PayPal has PYUSD, which is already in circulation. That's their stablecoin, so stablecoins are part of this. But the biggest thing is PayPal is still a juggernaut, Sacks: 439 million consumer accounts. You did something right there 25 years ago. It has stood the test of time.

David Sacks

I know. It's amazing. It really is.

Jason Calacanis

Isn't it amazing that it's still that strong? It's weird when brands keep going for that long.

David Sacks

But the problem is that the product is getting very long in the tooth. I think it's only growing 7% a year, which is a lot on the base that it's grown to.

Jason Calacanis

It's a big base. Yeah.

David Sacks

It's a big base, but the product has become somewhat obsolete, and in a way, it's a legacy product. I'd be curious to hear from the Stripe guys how they would fix that, because I think that's a very hard problem to fix. Maybe they wouldn't. Maybe they would just run it more efficiently and milk it for all it's worth. I think there's a different question.

Jason Calacanis

Kind of do a private equity play.

David Sacks

I think the different question—

Jason Calacanis

What's the work each mean?

David Friedberg

I think there's going to be more of these kinds of deals. If you look at Ryan Cohen's bid for eBay, I think it's probably a second dot on a line that I think is emerging: AI-native folks are looking at first-generation digital-native businesses that have become mature, old, and stale; aren't run by the founders anymore; have not yet realized the opportunities with AI; have not yet realized their potential; and are overspending in a lot of ways.

And when you take a look at those businesses as a modern-day AI operator, you're like, "What the hell? This thing is so underutilized." They're not using their network well, they're not operating well, they're overspending, they're not using AI well, and there's a set of opportunities that become quite obvious.

I think the capital markets, as we've seen with Josh Kushner's roll-up of accounting firms, and with a project like this from General Catalyst, can use capital to go buy traditional services businesses and AI-ify them. I think this is part of a line of maybe looking at traditional digital businesses and AI-ifying them, and there's a long list of these. There's a couple dozen of them.

So I think if you looked at the public markets and said, "Hey, where are all these software companies and network businesses that emerged in the early part of the internet, or even in the more recent part of the internet, aren't run by their founders anymore, and have stalled out?" there's a massive opportunity.

Now, the question as a capital provider is: Who do you partner with to go and execute that operational revival of that business? You're not going to go hire some McKinsey consultant to do that work for you. It's got to be the best of the best. It's got to be the right players in the business.

So I think Ryan Cohen has proved his mettle, obviously, with some of the things that he's done with Chewy and GameStop, and that's obviously debatable. I spent some time interviewing him to understand his processes.

Jason Calacanis

This was on the All In interview program. You can go to our channel and find it there. It's last month.

David Friedberg

Thanks for the plug.

Jason Calacanis

Yeah.

David Friedberg

And obviously, when it comes to payments, who better than Stripe?

Jason Calacanis

Yeah.

David Friedberg

And maybe Jack Dorsey plays a role here. And by the way, if you think about that $17 billion equity contribution, what that technically means is Stripe is selling and Block is selling $17 billion of equity to the cash investors. That cash is then going to buy PayPal. Therefore, Stripe and Block end up owning a piece of PayPal.

The private equity investors own a piece of Block and Stripe, and what is not clear in the deal documents that were published, because I don't think it's relevant to the public markets, is who's actually going to operate PayPal post-close.

David Friedberg

And my bet would be that they're going to hand it over to the Stripe guys and say, “You guys go for it.”

Jason Calacanis

Yeah, I think that's clear. They're the most qualified, and they will have the biggest stake in it.

David Friedberg

So I will make a prediction. I think that eBay and PayPal are probably the beginning of a wave of mega-deals of, call it, flaccid digital businesses—

Jason Calacanis

Okay.

David Friedberg

—that can be revived with the blue chew of capital and the right operator.

Jason Calacanis

You have Chamath's attention. Go ahead.

David Friedberg

—that can be revived—

Jason Calacanis

Okay.

David Friedberg

—and I think that there's probably a big wave of this to come.

Jason Calacanis

Again, Rowe?

Chamath Palihapitiya

The other thing is this is probably not the final clearing price. I think the price is probably another 10% to 15% higher from here, and I will say that there's a certain individual who must look very closely at putting in a competitive bid.

Jason Calacanis

Oh, a certain individual who may have his fingerprints on the original PayPal—

Chamath Palihapitiya

Correct.

Jason Calacanis

—who might also have $4 trillion or $5 trillion in market cap to play with, who also made a $60 billion acquisition recently.

Chamath Palihapitiya

Correct.

Jason Calacanis

We don't have inside information here. To your point, Friedberg, this is becoming a playbook. There's a company called Bending Spoons that just went public. They bought a bunch of non-founder-led assets: AOL for $1.4 billion, Vimeo for $1.4 billion, WeTransfer, Eventbrite, Brightcove, and Evernote.

David Friedberg

Chamath, have you spent time with him?

Jason Calacanis

I was just DMing with him.

David Sacks

No, no.

David Friedberg

He's awesome. I've hung out with this guy. This guy is an absolute frigging operational killer. He-

Jason Calacanis

In Italy.

David Friedberg

He bought Evernote.

Chamath Palihapitiya

Yeah, in Milan.

David Friedberg

And, yeah, he runs the whole thing from Milan. He bought Evernote, and he just goes in and diagnoses these businesses. He's like, “Where are you overspending? Where are you underspending? What are you doing wrong with the product, and what are you doing wrong with marketing?”

And he just frigging fixes it, and he's just a killer. He's taken all of these businesses that were called Web 2.0 businesses, revitalized them, rolled them up, and printed cash out of them. And he uses leverage—

Jason Calacanis

—and lowers the cost to run them.

David Friedberg

—and lowers the cost. He's used leverage to buy these things.

Jason Calacanis

That's the other big thing. He's using young, AI-first executives, from what I'm told.

David Friedberg

Totally. It's a great call-out, J-Cal. Bending Spoons is the roll-up of this sort of strategy, but for these mega-deals, I think there's more of them to come.

Jason Calacanis

I will say the higher-order bit here, which we talked about for a couple of years, was that M&A was on the ropes for a couple of years under the wrath of Lina Khan. Then, once Trump got elected, all the executives working in corporate development said, “Hey, looks like M&A is back on the menu.”

Now we're seeing deal after deal after deal get consummated. People are no longer scared of doing deals. Uber just bought Delivery Hero today. That's going to, like, jump their revenue by 20—

Chamath Palihapitiya

$15 billion.

Jason Calacanis

Yeah, and that's going to jump their revenue by—like, they're getting diluted 10%, and it's going to jump their revenue 24% or something crazy like that. This is going to be, I think, the big story of the next couple of years.

And all this liquidity—talking to LPs and family offices, which I do on a regular basis, they're all like, “Hey, when's your next fund? Hey, when's the next deal?” Because now people are believing in venture because of the SpaceX distributions and all this M&A. We have 4 or 5 companies that have been bought since Donald Trump was elected president.

Thank you to my president, Donald J. Trump, for putting M&A back on the menu, Sacks. M&A back on the menu. Why don't you make a bid, Sacks, for PayPal?

David Sacks

Been there, done that.

Jason Calacanis

Been there, done it. Okay, yeah.

David Sacks

No, but look, you have to have synergies.

Chamath Palihapitiya

There was a moment—this was like 15 years ago—where they asked Sacks to go back and be the CEO—

Jason Calacanis

That was right. I remember that. At the poker game. Yeah.

Chamath Palihapitiya

—and he and I immediately flew to Vegas and spent the weekend there to think about it.

Jason Calacanis

They're like, “You know what?”

David Sacks

Well, no, I never got the offer, but it was down to, like, the final 2 or something, and it was between me and someone else. Actually, they ended up going with some traditional credit-card executive.

To be honest, that's why PayPal has stagnated. As soon as it was acquired back in 2002, they basically blew out all the founders, all the founding DNA, and it was just run by consulting types.

You've got to remember, at that time, it was acquired by eBay, and Meg Whitman had worked at Procter & Gamble and Disney, and she'd spent about 8 years at Bain. It was a very corporate mindset. Among all the internet companies of that era, it was definitely the most corporatist.

They saw the founders—the founding generation at PayPal—as just a problem, just a bunch of cowboys they couldn't control. They made no effort to retain them, and I think they were relieved when they all left. And that's what created the PayPal Mafia.

Normally, in an acquisition, you'd lock up all the talent. But in this case—

Jason Calacanis

They locked them out. They're like, “These guys are too hard to manage. Change the keys.”

David Sacks

I've said for a long time it's a misnomer to call it the PayPal Mafia. It's really the PayPal diaspora. Our homeland was taken over, they burned our temple, and then kicked everybody out.

Jason Calacanis

Yeah.

Chamath Palihapitiya

Totally.

David Sacks

And that's why the whole PayPal Mafia got started with all those companies.

Chamath Palihapitiya

Yeah, you guys are real victims.

David Sacks

I'm not saying anyone's a victim.

Jason Calacanis

No, I'm joking. I'm joking.

David Sacks

Look, when you acquire a company, you get to decide—

Jason Calacanis

Yes.

David Sacks

—what to do with that asset.

Chamath Palihapitiya

Totally.

David Sacks

That was just the reality. But it's not like—I don't think anyone was bitter about it. They were all like, “Okay, this gives us the capital to go do the next thing we want to do.”

Jason Calacanis

Well, the new CEO, by the way, Enrique, is really aces. I've met him before, and apparently they're doing a great job, which is why they probably got these offers, because they've been tightening that business up for the last couple of years.

David Sacks

Well, no, the reason they got these offers is that the market cap was down to, what, like, $30-something billion? I mean, this is a company that was worth $200 billion, wasn't it, roughly?

Chamath Palihapitiya

$322 billion, I think, was the peak.

Jason Calacanis

Mm-hmm.

David Sacks

And before this offer, it was down to what, $30 billion to $40 billion?

Jason Calacanis

Yep.

David Sacks

So the reason why it's attracting offers is that it's so beaten up. And so now the question is, can anyone else do something with it?

David Friedberg

Sacks, to your comment that you've got to have synergies, doesn't it seem to be the case that in this era, the core synergy that any great operator can bring to the table in this sort of scenario is AI?

You can leverage, whether it be in this business or others, tools that drive automation, product development, improvements, and efficiencies across the organization—tools that make the product actually better for the user, et cetera—that simply aren't being well implemented.

David Sacks

Potentially.

David Friedberg

I mean—

David Sacks

Well, look, I think you have to have a product vision of how you would use AI to make the whole user experience better. And yes, you're right that you could just use AI to drive efficiencies, and that'll improve your profitability and earnings. On a financial level, you could make the acquisition work.

But it seems to me the existential issue for PayPal is that you're dealing with a product that's 25 years old. It's the same thing that we created back, like, 27 years ago. It's changed a little bit, but not that much.

The problem is that the interaction model is legacy. So unless you've got a vision of how to resuscitate and rejuvenate that product, I think it could be a good financial play, maybe. But—

Chamath Palihapitiya

I think they're buying the accounts.

David Sacks

Yeah.

David Friedberg

Yeah.

Chamath Palihapitiya

400 million users.

David Sacks

I mean, what you're saying, Chamath, is interesting because with Stripe, this is the advantage that Stripe has: They have a ton of merchants, right? They've become the preferred mechanism for merchants to basically accept payments via APIs.

I think they're doing about $2 trillion a year in annual transaction volume. I think PayPal is doing $1.7 trillion. So actually, Stripe is a little bigger than PayPal now.

But the thing that PayPal has that Stripe doesn't really have is the consumer relationship: over 400 million active consumer accounts.

Jason Calacanis

So you're right, Chamath, that if somehow you could combine the merchant relationships with all those consumer accounts and bypass the credit card networks, there could be a lot more on-us transactions.

Chamath Palihapitiya

Exactly. PayPal already owns Braintree, so now you have Stripe and Braintree, which effectively were competitors that won't be anymore. And then what Block gives you is an entire point-of-sale infrastructure, and you get Cash App. So you put it all together, and I think it's a shot across the bow for Visa and Mastercard.

David Sacks

That's where the value is.

Chamath Palihapitiya

PayPal already owns Braintree, so now you have Stripe and Braintree, which effectively were competitors that won't be anymore. And then what Block gives you is an entire point-of-sale infrastructure, and you get Cash App. So you put it all together, and I think it's a shot across the bow for Visa and Mastercard.

Jason Calacanis

Braintree is the other one that you just mentioned there, Chamath. That's important because that is a very strong business that people don't even know PayPal owns.

Chamath Palihapitiya

Huge business.

Jason Calacanis

Venmo also speaks to a lot of young people. So you're kind of getting two generations. You're getting Gen X and millennials, a lot of bang for your buck there.

Chamath Palihapitiya

But what Sacks said is true. They have enough of these things to go end to end on their own rails. That is a very important opportunity.

David Sacks

Yeah. The question is whether you can package it all together in a way that the consumer will actually choose, because it's one thing to say, "We take the merchant relationships of Stripe and the consumer relationships of PayPal and we put them together."

Chamath Palihapitiya

No, you don't do that.

David Sacks

But what if the consumer doesn't want that?

Chamath Palihapitiya

No, you don't do that. I think what you do is you go to places like all of the merchants that use Stripe and say, "We'll give you a 3, 4, or 5% discount." And they'll be like, "Okay."

Jason Calacanis

Yeah.

Chamath Palihapitiya

And so you'll see these prices just fall everywhere. Imagine if Shopify said to all their merchants, "Okay, you have two choices: the old way or the new way. The new way, you put another 2, 3, or 4% in your pocket." Of course they're going to pick the new way.

Jason Calacanis

Well, this is the paradox of modern M&A. If you look at protecting the consumer, this will ultimately be great for consumers. This is going to lower the prices. They're not buying this to—

Chamath Palihapitiya

Well, okay, you're saying something really interesting. It is so good for consumers if this were to happen. This is the exact reason why, if this had happened 2 years ago, this would have been the antitrust equivalent of a colorectal exam. You would not even get one step close to doing this deal 2 years ago.

Jason Calacanis

Oh, God.

David Sacks

Well, that's really interesting, actually. The key question with antitrust is, how do you define the market? If you define the market as APIs for merchants, then, JCal, it would be Stripe versus Braintree, and then the government would say, "You can't consolidate that share."

Chamath Palihapitiya

No, no, I know. Yeah.

Jason Calacanis

Right.

David Sacks

If the real market is Visa and Mastercard, that's the ultimate duopoly. And if PayPal can add competition to that market, which is infinitely larger than APIs, then it's actually pro-competitive. So how you define the market determines whether it's anticompetitive or pro-competitive.

Chamath Palihapitiya

Exactly.

David Sacks

It's the game.

Chamath Palihapitiya

Exactly. And those guys are smart enough, and they've read enough books, that they won't screw this one up.

3. Apple Sues OpenAI

Jason Calacanis

All right, let's get to the next topic. Somebody else is suing OpenAI. This time, it's Apple. On July 10, Apple filed a 41-page lawsuit against OpenAI over alleged stolen trade secrets. Apple says OpenAI stole its IP to develop its consumer hardware device.

Remember, we had Sara Fryer at Liquidity, and I probed her on this new device. She said it was very human and lovable. She gave us a little bit of the goods. Well, it turns out Apple is alleging that maybe this is partially its IP.

Tang Tan, Apple's former VP of iPhone design, is OpenAI's chief hardware officer. He allegedly directed Apple job candidates interviewing at OpenAI to bring, quote, "actual parts" to interviews to, quote, "show and tell" in the interviews. Chang Liu, a former Apple senior technical engineer, sent this text message to a still-employed Apple colleague: "LOL. I found out I can access the network storage. So funny."

During all of this, OpenAI has poached over 400 Apple employees over the last year or two. That's a big number of poaching. Apple and Tim Cook have seen enough, Chamath. Tim Cook greenlit this. As insane as this is, Sam Altman has found a way—found a way—to screw yet another party. He screwed Elon, his first benefactor.

Chamath, if you remember correctly, the default for iPhone AI was supposed to be ChatGPT. So Sam took this relationship where he got to be the default on the most important platform for AI, the iPhone, and now it's wound up in a massive lawsuit. What are your thoughts on this?

Chamath Palihapitiya

I haven't really seen Apple act very litigiously in 25 years in Silicon Valley, so that's obviously a concerning data point for OpenAI. They're very reactive more than they are proactive on these things, so there must have been something that really, really upset them.

So I don't know. It's going to take a court to sort this out. I don't really want to gossip because who knows what's actually going on and who said what and blah, blah, blah. But nobody should be stealing things from their former employer. Nobody.

Jason Calacanis

Obvious.

Chamath Palihapitiya

You're just not allowed. It's just obvious. These people are very, very smart and they're very successful, and that's why OpenAI probably wanted them, and that's why they wanted them. You come to them with the collective wisdom of what you've accumulated, and I think that's sufficient. You don't need to, especially as a senior person, do this.

So I just hope that this stuff isn't true, because I don't think that Sam or Sarah or anybody else there is trying to induce this to happen. I don't think so.

Jason Calacanis

Yeah. I doubt they induced it, but I do believe that it's true, or Apple wouldn't have brought it. Sacks, when we look at this, maybe you could open the aperture here if you want, or you can just go very detailed. The nature of the fact that we have a free market is that we don't have noncompetes in California, generally speaking. You can just—employment at will—go where you want.

But we have had instances. Waymo famously brought some IP to Uber. When they did, Travis and the team said, "Leave the building. Your job is rescinded. You don't get to bring that information here." In this case, it seems maybe they didn't induce it, but it occurred for some period of time. So take us through, big picture, what you think is going on here and what it means for the industry.

David Sacks

Well, like Chamath said, I have no idea what's going on here. This is a lawsuit. The facts are all alleged. We don't know. It's going to be adjudicated, so I really don't want to opine on what happened here.

But if people want to know, a very simple rule of thumb for how to avoid these types of disputes is: when an employee leaves their previous company and joins the new company, just don't take anything with you. The only thing you can bring to your new job is what's in your head. That's it.

Jason Calacanis

Your memories.

David Sacks

Your memories. That's fine. Whatever's in your head, you're allowed to take, but never leave with anything else.

Jason Calacanis

Never.

David Sacks

No thumb drives.

Jason Calacanis

No thumb drives.

David Sacks

Never.

Chamath Palihapitiya

Ever.

David Sacks

No CD-ROMs.

Jason Calacanis

No thumb drives.

David Sacks

No documents. No nothing. Just—

Jason Calacanis

Zip, zilch, nada.

David Sacks

What's in your head is okay, but that's it.

Jason Calacanis

Friedberg, any thoughts here on just the number of lawsuits that seem to be piling up over at OpenAI? Bad luck?

David Friedberg

A couple of dots make a line, I guess.

Jason Calacanis

Okay, there you go. Very well said. A couple of dots make a line.

4. The SpaceX Data Leak

Okay, xAI had a data leak this week. They launched Grok Build in public beta at the end of May. The newest coding model, Grok 4.5, powers Grok Build. I've been playing with it. It's extraordinary. It's a coding tool that works inside of Cursor.

SpaceX previously told users, "Nothing from your code base is transmitted to SpaceX servers during a session." But what actually was happening is that every time a developer used Grok Build, according to reports, the tool was sending their entire code base to SpaceX cloud servers without alerting users. Not just the files that were needed for that specific coding task—just everything. Passwords and API keys could have been pulled up there, along with all the change logs, et cetera.

The privacy setting was supposed to stop this, but it didn't work. SpaceX quietly disabled the upload on July 13 by flipping a switch on its servers. Elon Musk, friend of the pod, promised on X that all previously uploaded data had been deleted, I guess. In response, SpaceX open-sourced Grok Build. That's their harness, so that's another open-source win, or a win for the open-source community and AI sovereignty.

Have you got any kind of thoughts on this? Obviously, this was not intentional, but trust is important with these models, as we've been talking about for the last couple of months here on the All-In Podcast.

Chamath Palihapitiya

I would actually connect this to my comments on CNBC earlier this week, which built on top of Alex Karp's comments the week before.

Chamath Palihapitiya

Privacy in AI is very fragile and brittle, and this is despite the best efforts of great businesses. You may not like Elon for his personality quirks, but he is incredibly trustworthy. He's overly transparent, and so, to their credit, they shut it off immediately.

But my takeaway is that there are all kinds of non-obvious data-leak vectors lurking in AI. If you think that you're going to flip a ZDR switch—zero data retention, which is the magic term that the industry uses to tell you that everything's going to be okay—I think the answer and the message should be, “It's not going to be okay,” because you can't guarantee any of it.

So the model companies, when they give you these zero-data-retention policies, are probably trying their best. But I think the reality is you are leaking information where you don't know it, and they, despite their best efforts, may still have trapdoors that they don't even know about until somebody else figures them out, like in this example.

All of this speaks to the fact that you have to have a stratified ecosystem. You have to have third parties. Now, look, that's very biased for me because it's in part what we do for large enterprises at 8090 [?] when we implement our software factory. But the reason why it's working so well is this exact reason: You need an independent third-party layer to interface with these models and manage this exposure, because there are trapdoors everywhere.

David Sacks

And that's what Sacha just said in a really interesting blog post. Did you guys see that?

Chamath Palihapitiya

Yeah.

Jason Calacanis

Yeah.

Chamath Palihapitiya

I thought that was excellent.

David Sacks

“The Reverse Information Paradox.” That's exactly the takeaway that he left with. He was building on Alex Karp's supposed crash-out—the point that Karp made about how enterprises that have technical ability want control over their compute, models, weights, data, and alpha.

But he went further with that idea. He started with Karp's idea, but then he provided a recipe, a roadmap, for how enterprises should operationalize that. What he says is that enterprises have to establish a real trust boundary with private evals, proprietary learning loops inside the tenant, decoupled orchestration, and the explicit right to fine-tune their own output.

So he goes through a litany of fairly technical things that enterprises should do in order to achieve the operational control that Karp was saying enterprises really want over their AI compute, models, data, and alpha. It's really interesting. I think now there's a virtual, almost college-dorm-session-like discussion going on between the leaders of these companies, who are brainstorming some of these concepts and now extending them.

David Sacks

Mm-hmm.

David Friedberg

What's happening is you're starting to see the formation of not really an alliance, but an ecosystem that is trying to create alternatives to a monolithic, closed-model stack. That's where Anthropic and, to some extent, OpenAI want to go: They want you to be locked into their stack—their models, their harness. They control the data, all of that—and now you're starting to see all these different companies—

5. The Token Cost Reckoning

Chamath Palihapitiya

And you pay a huge premium for the privilege of having them do it, which is even more insane. I saw this data, and Nick, maybe you can find this companion clip. The companion clip I'd like you to find is Eric Gleiman, the CEO of Ramp, who was on Squawk Box, I think today, talking about a new feature where you can manage the token spending of your employees through your Ramp card.

But the data that I saw was that a million tokens on Lovable is about $56. That sucks. A million from Bolt is about $26, which is the same as Claude 4.8. A million input tokens on Grok is about $1.50. Zuck's is about $1.50. Elon's is about a dollar, and the Chinese models are 50 cents.

David Friedberg

Okay.

David Sacks

On top of the whole data-sovereignty issue—

David Friedberg

Bleeding your alpha away.

David Sacks

Can you imagine that you're paying $56 per million input tokens as well? For that risk? That is insanity.

Jason Calacanis

Bro—

David Sacks

I'm using Perplexity Computer, and they started supporting Groq. They already support GLM-5.2. When you're using Claude or OpenAI, you can only use their models.

So I started messing with the different models, and I gave them all the same basic PRD. I said, “I want to make a podcast player that deep-links.” If we were talking about, I don't know, Mythos, it would play me all the Mythos clips across all the different tech and business podcasts, but make them into one stream.

I thought this would be really helpful for me for prepping for the show and would just be interesting. I did it. It took a couple of hours, and it cost $11 on the new Groq. It was hilarious how cheap it was.

Jason Calacanis

Sure.

David Sacks

I'm sorry, did you try to do it on Fable to see how much more expensive it would've been?

Jason Calacanis

I didn't, because I was out of Fable credits on my $200 account. So—

David Sacks

Well, look at this clip here. Nick, play the clip from Eric Glyman. That's kind of interesting.

Eric Gleiman

We're thrilled to be launching Token Spend Management today. It's available to Ramp and non-Ramp customers.

David Sacks

Smart.

Eric Glyman

And he's exactly right. Over the last year—I looked at the stats this morning—token spend among Ramp customers has grown by 21 times.

Jason Calacanis

21 times. Not 21%.

Eric Glyman

21 times.

Jason Calacanis

We're talking about 21 times.

Eric Glyman

That's exactly right. So being off by a few pennies as a CFO actually might be quite nice. At the rate it's going, it might be several dollars.

And look, I think that for many CFOs, they're often very surprised by the bill, because what the AI companies have functionally set up is that you have a tab. You can spend as much as you want. It's very hard for CFOs to see proactively what people are spending on, and every time they introduce new models, the rates often go up.

Jason Calacanis

Right.

Eric Glyman

So the incentives are very misaligned. Part of what we're trying to do is make it easy for CFOs to see the spend, understand the spend, and control it.

David Sacks

Thanks, Nick. He's saying something so important there, because if your engineers are going off randomly in an unguided system and then just ripping through a million tokens at $56, what he's talking about is the eventual downstream impact on earnings.

Eventually, a bunch of these public-market CFOs are going to show up to Wall Street and they will have missed earnings because their OpEx, at some point, if things are 21x-ing every few months, will cause somebody to miss a quarter. I don't know who, but somebody.

I was speculating it would be a few pennies here or there, which they'd have to say was because of token spend. He's saying it could be as much as dollars at this rate, which also could be the case. I think the point that we're all trying to make is, unless you get control of this and you can directly say how much money you're making, this is a bridge to nowhere. It is a money-burning furnace.

Jason Calacanis

The good news is this is all creating a massive market opportunity, Sacks. Bittensor subnets, GLM-5.2 hosting, Grok 4.5—

Chamath Palihapitiya

Inkling. Inkling, Mira Murati's new model.

Jason Calacanis

Mira's Inkling. Everybody's now saying, “Hey, wait a second. I can give you a better deal. You're paying, like, $2? I can get you $1.”

Chamath Palihapitiya

No, no. People are paying between $26 and $56. They should be paying 50 cents.

Jason Calacanis

Exactly.

David Friedberg

The Inkling announcement was interesting, because I think the value proposition there is that she's explicitly saying, “Look, we're not frontier intelligence. We're just under that. But we're a platform for fine-tuning these open models, which are much, much cheaper, and then you can achieve the result you want based on fine-tuning.”

David Sacks

Right.

David Friedberg

And so that's really interesting. But these open models won't be around for very long if Anthropic has its way. That's where it's all going.

Jason Calacanis

There's a reason they want to stop it. They have such a monopoly—

David Sacks

Of course. You're selling most of the product for 50 cents per million tokens when they're selling theirs for $56. Of course you don't want that to happen. Of course you want to try to stop it.

David Friedberg

But that being said, they're still growing like crazy, just to be clear. You are seeing this explosion of interesting things happening with open models. Like you said, the latest Grok Build is open, Thinking Machines is open, and so forth and so on.

Chamath Palihapitiya

Nimo is coming.

David Friedberg

They're growing. They're still the industry leader in terms of revenue growth, so these things are happening side by side.

Chamath Palihapitiya

Yeah. I think the interesting thing is Eric would not have released this Ramp product unless CFOs were saying, “I can't control the spend.”

Jason Calacanis

Yes.

David Sacks

And then he's saying, “Well, here, let me build it for you.” If enough CFOs essentially turn that feature on and start to rate-limit how it's spent because maybe they're not getting the ROI, the engineer doesn't care about ROI. The engineer's saying, “I want to use the latest, greatest model.”

Jason Calacanis

Yeah, make me better.

David Sacks

And maybe you don't need it.

Chamath Palihapitiya

Maybe Mira’s right: for 95% of the tasks, you should be at one level lower, especially when it costs 1/100th the cost. But the engineer will never make that trade-off because they’ll never—

David Sacks

Totally.

Chamath Palihapitiya

—want to think about it.

David Sacks

You’re right.

Chamath Palihapitiya

And also, they’re not tied to the money. The CFO is tied to the money, and the engineer wants to explore using the latest, greatest thing.

And until those two things have a reckoning—

Jason Calacanis

If you’re booking your travel, you don’t even see the price. You’re like, “Yeah, just put me in business class. Put me in a nice hotel.” The travel department handles that.

Chamath Palihapitiya

You’re saying something really interesting. What percentage, if you had to guess, of Fable five prompts are just average meshugana that should be running on—

Jason Calacanis

98%.

Chamath Palihapitiya

Yeah.

Jason Calacanis

98%.

Chamath Palihapitiya

Yeah.

Jason Calacanis

I was using it for stupid stuff that I could be using Qwen for.

Chamath Palihapitiya

Yeah.

6. AI Moves To The Edge

Jason Calacanis

This is just my micro-prediction here: Mark Gurman, who’s the most in-the-know guy when it comes to Apple, says we have this new CEO coming in for Apple.

Chamath Palihapitiya

John Furness.

Jason Calacanis

Yeah. He’s a hardware engineer. M7 Ultra, because we’re on M5 chips now. You can get 256 or 512 gigabytes of RAM. He says M7 Ultra is going to support as much as 1.5 terabytes. That’s double what they’re already supporting.

So if you think about frontier models, like the last generation, this is an Opus-level model running on your Mac Studio. You guys all use Mac Studios. You’re rich venture capitalists, whatever. You’re like, “Yeah, I’ll take a $4,000 or $5,000 computer.” This is going to change everything.

You’re going to have employers go, “Oh, I can just run 90% of my workloads—99% of the workloads—on the local Mac Studio?” I think Apple is a screaming buy right now. That’s not financial advice, but my Lord, that company could just run the table on AI if they get this right. All right.

David Sacks

Apple?

Jason Calacanis

Yes, because they’re going to make such a fortune—

Chamath Palihapitiya

You’ve got to just let them move on, Sacks. You’ve got to just let them move on.

Jason Calacanis

No, no, I’ll tell you. Let me explain. It’s just like the iPhone. Everybody laughed at the iPhone.

David Sacks

No, they didn’t.

Jason Calacanis

When the first iPhone came out, many people laughed at it.

Chamath Palihapitiya

Not true.

David Sacks

Steve Jobs did.

Jason Calacanis

I know who did.

David Sacks

That was it.

Jason Calacanis

That’s true.

Chamath Palihapitiya

Not true.

Jason Calacanis

Steve Jobs was the big one. You could hear—I can still hear him laughing. No, if you think about how they make money off hardware, off their devices, they will put so much downward pressure on Claude and OpenAI by just putting local models on their devices and supporting them with this memory architecture. It’s going to be wild when people have unlimited tokens on their desktops. I’m telling you.

Chamath Palihapitiya

I don’t know if you saw this, but there’s a very large solar company called Sunrun. They just announced this week that they’re making distributed data center blocks that you can put in your house. Another company that did it is called Span, which partnered with NVIDIA.

So, to your point, Jason, you’re seeing this fragmentation and distribution of edge compute, which I think is a theme. Definitely a theme.

Jason Calacanis

Well, it’s also chasing energy, right, Chamath? If you’ve got some solar, if you’ve got excess battery power, hey, we power up your batteries at night cheaply.

7. The Electricity Shortage

Chamath Palihapitiya

I think I told you this last week: We are so massively short electrons. By 2050, the United States of America will be 2.5 Californias’ worth of energy in deficit. 2.5 Californias.

California is the fourth-largest economy in the world. We will be short 2.5 times all of the energy consumed by California by 2050. This week, there was an auction by this huge utility called PGM, which serves Pennsylvania, New Jersey, Maryland, and 13 states. That auction is where they publish a forward curve and say, “Hey, listen, guys, here’s my forecasted load, and here’s how much energy I need.”

People sign up to essentially get paid a guaranteed rate every day so that they have to fork over the energy in the future, kind of like a forward option. They needed 7 or 8 gigawatts. They had 156 megawatts or something show up. We are in such a bad place right now on electrons and electricity prices.

Jason Calacanis

Did you see what our boy did this week?

Chamath Palihapitiya

We need—we need—this is behind the meter, which is different. Elon needed to do this, by the way, just so you know, because there’s an issue in Memphis where he was very clever about how he was able to get Colossus off the ground.

Jason Calacanis

Explain this.

Chamath Palihapitiya

When you try to power a data center, typically you have what’s called grid power. You go to the utility in the area and say, “Hey, please run me a line off of that main transmission line,” and that’s how you power your data center.

When that runs out or is so backlogged, you have to do what’s called behind the meter, which means on your own property that you own, you build something for yourself. Now, there’s a problem with that. You would think, “Well, that’s smart.” Yes, but like everything in America, there’s regulation on top of regulation on top of regulation.

One of the most complicated regulatory schemes that you have to overcome is clean-air permitting. So even if you say you’re going to do behind the meter, then you’re like, “Well, what can I do?” Solar you can do, but it takes too much space for most places. Batteries you can do, but you need to generate the electricity in the first place, so people use natural gas.

So Elon cleverly bought a ton of 18-wheeler engines, basically.

Jason Calacanis

He bought the company that makes all this and brought them to—

David Sacks

Mobile turbines.

Chamath Palihapitiya

Yeah, mobile turbines.

Jason Calacanis

Yeah, the turbines.

Chamath Palihapitiya

And then just pinned them to the ground and ran them. Those are for personal use, essentially, and so they came under the clean-air permitting requirements. But then when you act as a block, you could make the claim that it doesn’t.

Now, there are new solutions, like Bloom Energy, which allows you to have huge installations and still fall under the personal-use clean-air permit. For all of Elon’s future capacity, he needed to have this in place so that he gets the clean-air permits and is able to have a clean line of sight to continue to build domestic data centers.

Anyway, there’s your little TED Talk on energy, but we are in a bad place, guys, and it’s only getting worse.

8. New York Bans Datacenters

Jason Calacanis

Speaking of data centers, Sacks, everybody’s favorite socialist governor, Kathy Hochul, in the great state of New York, my hometown—

Kathy Hochul

Powered by fossil fuels, they drive up our carbon footprint. They occupy massive amounts of land, potentially displacing agricultural space and open spaces. The bottom line is progress shouldn’t arrive with a higher utility bill, depleted water supply, or noise pollution. So we have no choice but to address these challenges created by these massive facilities. That is why—

Jason Calacanis

She’s so dumb.

Rupert Darwall

—today I’ll be signing the nation’s first-ever statewide moratorium on hyperscale data centers.

David Sacks

Everything she’s saying there is a false accusation, so let’s just go one by one. She’s saying that they eat up all of the power. Well, look, if you connect to the grid without producing more power and you force data centers to compete with residential ratepayers, then, yes, you could drive up utility prices.

However, if you do what Chamath said and let them build behind the meter, then they bring their own power. That’s what the president has advocated for since the beginning of his administration: Let the AI companies become power companies. So that is the way to solve the energy problem, or the utility problem.

Then she’s talking about eating up land. The reality is these data centers are a model of land-use efficiency. We have a ton of land in this country, obviously. You can find places where there is enough open land to build a data center. The economic impact and value of a data center relative to the land use, again, is one of the best ROIs there is.

The supposed noise pollution is largely made up. That can be dealt with. You obviously don’t want to put these things right next to a residential area, but create a little bit of distance and it’s fine. The whole water-consumption thing is—

Jason Calacanis

A hoax.

David Sacks

—largely a hoax. Modern data centers recirculate the water.

Jason Calacanis

Closed-loop systems.

David Sacks

Yeah, and I think there was a study that showed that a typical data center uses the same amount of water as 2.5 In-N-Out Burger chains.

Jason Calacanis

I mean, just go after the almonds if you’re concerned about water, people. Please.

David Sacks

There are many uses of water that are way more wasteful, like golf courses.

Chamath Palihapitiya

Yeah.

David Sacks

I mean, there are many uses of water that are way more wasteful.

So when you compare economic impact to all these different things, data centers are, honestly, one of the best things we could be building as a nation, but—

Chamath Palihapitiya

And taxes. There are all these taxes and incremental revenues. Did you see the article where, I think it was in North Dakota or something, teachers were getting $30,000 and $40,000 bonuses from all the tax revenue that was coming in? There are all these upsides.

David Sacks

That's right. They generate a lot of tax revenue. They've created a blue-collar construction boom. It's not true that there are no jobs once they're built; you do have ongoing jobs there. And one final thing, just on the point that Hochul is making: she said it created a lot of pollution. Natural gas, which is how most of these data centers are powered, is one of the most clean-burning sources of power that we have.

Chamath Palihapitiya

100%.

David Sacks

These data centers have become the scapegoat for all the angst that people have about AI, and it's become this very clumsy way of trying to throw a wrench in the gears of innovation and just slow the whole thing down.

Jason Calacanis

Well, all I have to say is, welcome to Texas. We've got plenty of land.

David Sacks

For now.

Jason Calacanis

And what's so stupid—

David Sacks

But yeah.

Jason Calacanis

—about her proposal and her talk, aside from the things she got completely factually incorrect, is that New York State is 80% underdeveloped. You drive upstate, folks. You're thinking of New York City. Yes, New York City's packed. You go upstate; 70% to 80% of the land in New York State is undeveloped. There's so much land, it's ridiculous. New York is giant.

David Sacks

Well—

Jason Calacanis

It's giant.

Chamath Palihapitiya

By the way, on this topic, this week I just want to give a shout-out to Senator Dave McCormick. He had a defense and innovation summit in Carlisle, Pennsylvania, at the Army War College, which a bunch of us went to. POTUS came, gave a speech, and had a CEO roundtable. A lot of defense company CEOs, et cetera. But Chris Wright was there, Sacks, and—

Jason Calacanis

My guy.

Chamath Palihapitiya

He's great. And Chris mentioned this insane story. He said, “You know, there are a lot of common funding patterns among these people who are protesting the data centers,” because Dina Powell asked this question on stage. And he said, “You can actually trace it back to the same people who, in a different era, were protesting fracking.” So he was saying these are all just hobbyhorses that they use to raise money and have a job. They're professionally paid protesters. They just show up out of nowhere. I didn't realize there was such a commonality, but they're the same people.

David Sacks

The thing that I just can't understand, for the life of me, is why Anthropic is still funding these groups that want to put the kibosh on new data center construction. There's one called Public First, where Dario just gave his first seven-figure contribution, and then a bunch of other employees at Anthropic gave to it. All these groups are trying to slow down AI development with new regulations and by making it harder to build new data centers. At a certain point, you just have to wonder: is this regulatory capture, or have they just lost the plot?

The number one thing slowing down the growth of Anthropic's revenue isn't demand. I think it's the availability of compute in data centers. So you're just wondering, what is the point of all of this?

Chamath Palihapitiya

It's so true.

David Sacks

I was talking to someone in politics about this, and the theory they had was, well, the Democrats aren't going to pause the data centers forever. They're going to pause them until they feel like they're in enough control that they can dictate all the rules. In other words, they're calling this a moratorium, and I think it does mean that the data centers are going to stop, but eventually they're going to be in a position to say, “Okay, here are our terms if you want to turn these things back on,” right? “You want to lift the moratorium.”

And then that's when we get this big-government, Democrat-defined AI regime. You know that it's going to consist of a new regulatory agency, new speech controls—the whole trust-and-safety agenda from social media will be ported over. This was what this one person I was talking to was speculating is the real agenda: eventually, once Trump is no longer president, or in some future Democratic administration, they will eventually lift the moratorium, but on their terms.

Now, I think that's a really dangerous thing to do because Trump is president for another 2 years, and then no one knows what's going to happen after that. And even if you lift the moratorium in, say, 2.5 or 3 years, it's going to take a couple of years for those projects to even ramp back up. So when you start talking about a moratorium on data centers, it's not like a few-month pause. It's probably a good 5 years at least before you can get another data center switched on in the state of New York.

Chamath Palihapitiya

Just so you know how bad it's gotten, there's a curve that you can use to price data center assets, and I think you guys know this, but I have this portfolio of these assets that my partner Nita and I have accumulated. What's so interesting is when we talk to all of the hyperscalers about giving us a price, because we're trying to figure out whether we should keep it, build it, or just sell it, the most incredible thing is how extreme the price is at the front end of the curve when you have verifiable, energizable power today.

And the reason is exactly everything that you're saying, Sacks: when you look out into the future, we've said this before, but about 40% of all these projects are getting mothballed and stopped. So it's creating this massive deficit of available energy to actually drive the use of AI.

To the extent that you actually want drug discovery, cancer diagnoses, better healthcare, or better legal advice, we may actually not be able to service it based on all of the demand that exists because the power isn't there, the energy isn't there. And the reason why it's not there is because folks are just reflexively protesting something that they clearly don't completely understand. So I think it's a really big problem.

Jason Calacanis

We're going to have GPUs chasing energy. Where's their energy? Just drive the GPUs there. That's what's going to happen, right?

David Sacks

Let me add one layer to it: they're not only trying to stop data centers from being built in the US, they're trying to stop data centers from being built internationally, in our friends, allies, and partner countries. And the way they're doing that is that the same political forces that are stopping data centers are also behind all these new export controls on chips. So they want to make it—

Chamath Palihapitiya

Yeah.

David Sacks

—harder and harder to export chips to more and more countries, including our friends and allies. So there's not going to be data centers here. There's not going to be data centers in our allies. I mean, where are we going to put these things?

Jason Calacanis

Yeah, and some of those allies—

Chamath Palihapitiya

I'm surprised—

Jason Calacanis

—have unlimited energy: the Middle East. If you want some data centers—

Chamath Palihapitiya

Well, what's funny, Jason, is we did a bunch of Middle East data center stuff, and then it stopped, meaning there wasn't this growth that I thought would happen because it's a very conveniently placed geography. It's the Middle East for a reason, and so—

Jason Calacanis

Yeah.

Chamath Palihapitiya

—you can serve 4 billion people very quickly, in under 200 milliseconds, from there. Instead, what happened was there was this explosion in Asia, and specifically in Australia, which surprised me because I would've thought those folks are a little bit even further out on the DSA—far left. I thought these things would not have happened, but they were able to get big deals done.

So in this weird way, you have all of these other countries running to try to embrace this stuff quickly. They've done a decent job. They're doing stuff to displace some of the energy that's needed in the US. But the problem is we need to have enough surplus here because this is where most of the commerce is going to get created, which I think should power the—

Jason Calacanis

These are luxury regulations. You can afford, if you're New York State or California, to be like, “You know what? We don't need this. It's a luxury for us to have an extra data center.”

Chamath Palihapitiya

But I think the fact that—

Jason Calacanis

If you're Australia, you might really need the money. If you're Texas—

Chamath Palihapitiya

Well, yeah.

Jason Calacanis

—you might really want the money. Nebraska might want it.

Chamath Palihapitiya

So this is what's so crazy: virtue signaling only goes so far until your debt-to-GDP is high enough and/or your productivity is low enough and/or your foreign direct investment is low enough, where you're like—

Jason Calacanis

Yeah.

Chamath Palihapitiya

“All right. You know what? Screw all that. We're just going to build a data center.”

Jason Calacanis

And by the way, I don't know if you saw the—

You know, even if you just think about fiber and the milliseconds you're talking about, yes, you can get to 4 billion people. But I don't know if you saw the giant Starlink versions now. They make a really big version. I think, Sacks, you got one of the enterprise versions. But there's an even bigger enterprise version, and they can bundle them together, and you're starting to get to 10-gig, 20-gig setups. So that means you could start putting these things almost anywhere.

David Sacks

Yeah.

Jason Calacanis

Which also adds another wrinkle.

David Sacks

Rupert, can we see your clip, the thing that you were mentioning before?

Rupert Darwall

This is not as prevalent in the Middle East, where you have monarchies and governments that aren't ruled by democracy. But in democracies, we see this anti-data-center movement taking hold. This chart is something that, for me, always played a role in my understanding of where the incredible anti-GMO sentiment came about in the United States.

Jason Calacanis

This is great.

Rupert Darwall

Russia Today, this Russian media outlet, launched in the US in 2010. They were kicked out of the US by Biden in 2022. You can see that prior to Russia Today existing in the US, there was no anti-GMO sentiment. GMOs had been around since 1996. That's when they first had their big commercial launch in the US, and they were pretty prevalent for 14-plus years before everyone started to think, “GMOs are bad. We’ve got to get rid of GMOs.”

You could ask people 100 different ways, very pointedly and specifically, about the facts on the matter and the science of GMOs and all this sort of stuff, but everyone always had a reason why they didn't want them, similar to what we're hearing now with AI and data centers.

It turns out that if you track back all the media that had all this anti-GMO sentiment, which ultimately got picked up by the mom bloggers, put into social media feeds, and ultimately accepted by everyone as truth, a lot of it originated in this Russian media push that happened around this era. You can actually see this on the Google Trends data that shows GMO and its kind of rise-up.

As Russia Today started to get cut by different media outlets, and people stopped retweeting them, stopped reflecting them, and stopped writing articles that followed Russia Today, the anti-GMO sentiment declined in the US.

I think you can see this going back decades. There's this effort that the KGB designed during the Cold War called Directed Measures, which was really meant to try to create an influence campaign by affecting media—putting this kind of propaganda out through foreign media, particularly targeting Western democracies.

You could argue that maybe you could trace back what happened in Germany with nuclear energy as being similarly originated, but there have been a series of these pushes that seem nonsensical if you're fairly rational and can have an objective debate about the scientific merit, the economic merit, and the benefits of these technologies.

For some reason, what we call the activist community becomes heightened to them, says that we've got to get rid of them, and everyone has these different, scientifically unfounded reasons why they want to get rid of them. And you're like, “Wait a second, how did we end up in this place where we're literally handicapping ourselves?” I think we're seeing something similar happening with data centers in the US today.

The funding of the NGOs, as they're being called, the media that's supporting this, the retweeting of the media—and then you ask people: There was a poll that came out today, and something north of 50% of Americans believe that data centers increase the cost of water and electricity. Even if the data center is fully recycling the water and producing its own electricity, there's still this kind of repugnant reaction to the data center.

There has been this deeply sown psychological shift that's happened in the United States, and people have these attitudes: “I hate the rich, I hate tech, I hate AI, I don't want any of this stuff.” But where does it all come from? I do worry that there's some degree of foreign—

Chamath Palihapitiya

Influence.

Rupert Darwall

I don't love the word “influence” because everyone captures it.

David Sacks

Well, for sure.

Rupert Darwall

But there is some degree of this—

Chamath Palihapitiya

Interference. Yeah.

Rupert Darwall

Yeah, I would say there's foreign interest. Let's call it that.

Chamath Palihapitiya

No, I think it's more than that.

Rupert Darwall

There's foreign interest, psyops.

9. China Targets AI Debate

David Sacks

Just 1 month ago, OpenAI published a blog post called “PRC-Linked Influence Operations Are Targeting AI Debates in the US,” and Politico covered this, and a lot of other sites covered this. Basically, what they are saying—and in fact, many people are saying—is that China is behind a lot of these influence campaigns to shape US attitudes on AI data centers.

Chamath Palihapitiya

It makes sense. It makes a lot of sense for China to do this.

David Sacks

Yeah, and there's going to be a congressional investigation of this. It does make sense because it is in their interest, right? If they can stop us from building this necessary infrastructure, then that's a way for China to win the AI race.

Chamath Palihapitiya

If they can convolute the market, if they can incentivize Anthropic to pull the ladder up, if they can kill open source in the United States and constrain demand or the optionality and choice of lower, cheaper models, think about that for a second. At $56 per million input tokens versus 50 cents for the rest of the world, all of a sudden it doesn't take a company that's much worse than you to beat you when your cost is 50 to 100 times more.

Chamath Palihapitiya

Right.

David Sacks

That's just the math.

Chamath Palihapitiya

The math ain't nothing.

You know, Sacks made the point that these enterprises are not just paying for AI with money. They're paying again by feeding those frontier models their proprietary knowledge and all their alpha. So it's like a double whammy.

David Sacks

Double whammy.

Chamath Palihapitiya

It's more expensive, and you're potentially mortgaging your future.

David Sacks

Look, let's be honest. It is obvious where foreign governments have an enormous incentive to try to manipulate and influence the comings and goings in America. I think we should just acknowledge that. The idea that that doesn't happen is very naive.

The question is, we have to be able to call it out and put our finger on it, because otherwise what is clearly happening is that a lot of Americans will just fall for this, and they will not think from first principles.

David Sacks

We have a huge moral panic going on with respect to AI. When you talk about catastrophes that could result from AI, what are we talking about? We're talking about things that might happen in the future. Nothing resembling this has happened yet.

David Friedberg

Job loss.

David Sacks

Or job loss.

David Friedberg

Job loss.

David Sacks

None of it's turned out to be true. We haven't seen any of it so far, but we're on the threshold, I think, of destroying the crown jewel of our economy, which is the system of free-market innovation that we have—this culture of rapid iteration, where anyone with a good idea can go raise risk capital and start their idea, start their company.

Now we're talking—I mean, think about how far the Overton window has moved. We're actually saying that creating a FINRA for our industry might be better than all the alternatives. FINRA is a bunch of stockbrokers writing rules. When's the last time there was ever any innovation in that sector? I guess Robinhood made trading free. That was it, right?

David Sacks

Yeah, that was a big one.

Chamath Palihapitiya

That was it.

David Sacks

It hit the order flow.

Chamath Palihapitiya

Okay, but that's not real innovation. That's an innovation with respect to a pricing model, and we're actually saying that that might be the least-bad alternative: having the equivalent of a bunch of stockbrokers creating new rules that all these AI companies are now going to have to abide by.

David Sacks

It's crazy.

Chamath Palihapitiya

We are going to throw away the lead that we have in this. And by the way, Kimi K3 just came out, and people are saying it's now right up there. It's very, very close to the frontier. We may have months on China, if that, and we're going to create all these crazy rules and new regulatory bodies for risks that have not manifested yet.

David Friedberg

It's worth monitoring the situation, but it's not worth panicking. You should monitor the situation with self-driving cars and job loss. China is certainly doing that.

They just stopped giving out permits for self-driving cars, as an example, because it's going so well and they're losing jobs. There are people who are getting—there's a little civil unrest—so they just said, “We're going to make self-driving cars licensed.” They're not giving out any more licenses: a moratorium on licenses for now.

It's worth watching Mythos, and if it could hack your system, Palo Alto Networks is checking it out, and other people are checking it. It's all worth monitoring, but there is no disaster here today because of AI.

David Friedberg

Nothing's jumping out of your ChatGPT window. The worst-case scenario is you blow out some tokens. Okay, great.

David Sacks

It's crazy. There's only a handful of companies that are even at the frontier, and they all have safety testing and red teaming and all the rest of it.

Chamath Palihapitiya

Yeah, they're doing a good job.

David Sacks

Yeah.

Chamath Palihapitiya

They're doing a good job.

David Sacks

I'm not saying stop that. I'm just questioning whether we need some vast regulatory apparatus now to start doing all this rulemaking.

Jason Calacanis

It's certainly premature, and we did this because of science fiction and Dario saying all jobs are going away. That was the most ridiculous thing. When he said it, he seemed panicked that it was going to be 80% or 90% of jobs in 2026. What was his claim? Nick, get the exact claim. I think he said 50% of jobs, right?

David Sacks

No, he said, “50% of entry-level knowledge worker jobs are going away within 1 to 5 years.” That was 1 year ago, so—

Chamath Palihapitiya

It's a little ridiculous.

David Sacks

He's been in a state of panic since GPT-2.

Chamath Palihapitiya

People don't even know how to use the tools yet.

David Sacks

Remember, they wanted to have regulatory approval for models that use 10²⁵ FLOPS, right? Every single AI model is well past that threshold now.

Chamath Palihapitiya

Yeah.

David Sacks

And we haven't seen any of the harm. Look, they thought that 10²⁵ FLOPS would be enough compute to create the Terminator, to create Skynet.

Chamath Palihapitiya

No offense, Friedberg, but one guy's panic attacks, one guy's anxiety condition, might have shaped the whole course of history here. Does Dario have an anxiety issue where he's overly concerned about this stuff, or is it just delusions of grandeur? Come on the pod, Dario. The invite's open. Come hang out with the boys.

David Friedberg

I'm sure he'd love to come on the pod after you just accused him of having a panic attack.

Chamath Palihapitiya

He seems like he's in a perpetual one.

David Sacks

No, let me tell you.

Chamath Palihapitiya

Am I wrong?

David Sacks

Listen, it could be psychological, but I actually think that there's a strategy that makes a lot of sense, and it's a very simple, straightforward strategy. Number 1: brand yourself as a safe AI company. Number 2: ban unsafe AI. Number 3: profit.

Chamath Palihapitiya

Yeah, there you go.

David Sacks

That's the strategy. Kind of brilliant.

Jason Calacanis

All right, everybody, go to allin.com/events and sign up for the All-In Summit in September. Scholarships are open. Let's do a quick, amazing, deep, robust science corner with our boy, David Friedberg.

David Friedberg

Before we get into the science corner, I'm gonna give a shout-out to Ronnie, dog for adoption. I Love Family Dog Rescue in Sonoma. Check out his Instagram link in the description. This dog needs a home. He was fostered, and he lost the foster home. Someone come and grab him. He's awesome.

Jason Calacanis

God, here he goes again.

David Friedberg

All right, let's get into science corner.

Chamath Palihapitiya

This is what we're doing now?

David Sacks

It's on your side.

Chamath Palihapitiya

What? This is what we're doing? To try to get more IQ points?

Chamath Palihapitiya

That dog looks delicious.

David Friedberg

Gross.

Chamath Palihapitiya

Tucker, fuck you.

David Sacks

You don't live in Sri Lanka anymore, Chamath.

David Friedberg

Yeah, seriously.

Chamath Palihapitiya

Oh, Sri Lanka taking a stray. Oh, my God.

David Friedberg

Yeah.

Chamath Palihapitiya

Oh, there you go.

Chamath Palihapitiya

How do you marinate that dog in Sri Lanka?

David Friedberg

Do what you gotta do in Sri Lanka.

Chamath Palihapitiya

Is it just salt and pepper, Friedberg, or do you like something else? Just a little salt and pepper?

David Friedberg

12-hour marinade? You use Beaujolais Nouveau? What is it?

Chamath Palihapitiya

Do you like a little yogurt and garam masala? Maybe do a little tikka dog?

David Friedberg

Okay. Okay, spicy.

Chamath Palihapitiya

Little tikka masala?

David Friedberg

Do you guys want to talk about reversing aging?

David Sacks

Yes, I want to talk about it, but I gotta drop. All right, guys. See you later.

Chamath Palihapitiya

I gotta go too.

Jason Calacanis

Bye.

Chamath Palihapitiya

I gotta go to the Eiffel Tower, pal. Pal, pal, fuckers.

David Friedberg

I'll cover it. The audience will stick around. Science corner. All right, so Chamath, you can drop too if you want. I'll cover science corner solo.

10. The Aging Enzyme Breakthrough

In the past, we've talked about Yamanaka factors, which are these proteins that can go into cells and reverse the aging of the cell, and the cell starts to act young again. Pretty amazing, and there's a lot of advancement happening on that front. But this paper that came out just this week, which everyone's kind of going crazy about, was put out jointly by Calico, Google's super-secretive age-reversal startup, in partnership with a group called Reval Pharma.

What they focused on was what's called the extracellular matrix, the parts outside of the cell that age. What does aging actually look like outside of the cell? Over time, sugars and fats bind to proteins in the area between our cells, and they accumulate and don't get cleaned off. As they accumulate and don't get cleaned off, they make it harder for your body to clean out and maintain that area. It causes stickiness and binding, which reduces mobility and ultimately leads to things like wrinkles in our skin and makes it harder for our joints to move.

Chamath Palihapitiya

Is that visceral fat? Is that what visceral fat is?

David Friedberg

No, it's called glycation, and it's the binding of sugar and fat to the proteins that sit in that extracellular—

Chamath Palihapitiya

In between the cells.

Jason Calacanis

Yeah.

David Friedberg

In between the cells, exactly. It's that whole gunky area in between the cells that, when you're young, works well. Everything's smooth. The proteins get replaced if they break down. As you get older, sugars and fats stick to these proteins, block them up, and as they get blocked up, your body can't repair them or clean them.

More importantly, it changes the structure and the shape of those proteins, so things like collagen that are far apart stick together. That causes things like wrinkles and immobility. It also causes inflammation, because those proteins look different than they're supposed to, and your body starts to attack them, which activates inflammation. That's one of the reasons why we get more and more inflammation as we get older.

One of the key advanced glycation end products—that's the term for these things—is called CML. CML is the predominant molecule that gets formed in this extracellular matrix and drives aging, and nothing breaks it down. These scientists set out to try to create an enzyme—an enzyme is a protein that breaks something down—that can break down CML.

Remember, a protein is just a series of amino acids, and those amino acids are programmed by DNA. You can use 3 letters of DNA to make an amino acid. You can literally print DNA, put it in a bacterium to print proteins, and then test those proteins to see what they do. That's the modern era of protein synthesis and protein testing.

These guys took the target, which is CML, and tried to figure out how to degrade CML, clear that extracellular matrix, and reverse aging. They started with AlphaFold and used AlphaFold to find a protein that could bind to CML and activate an enzymatic process that would break it down.

They took that protein from AlphaFold, which comes from a bacterium, produced it, and started to test it. Then they started to find some of the binders, or the parts of that protein, that they could make better. They used DNA programming to change it, and they made hundreds and then thousands of variants to measure activity—which is how good each one was at breaking down the CML. They did this recursively through 5 different cycles.

Eventually, once they had gotten it breaking down the CML really well in a test tube, they started to test it on the proteins that we find in our bodies: casein, collagen, retinal proteins, which are in your eye, and hemoglobin. They were able to get rid of 52% to 97% of the CML, just degrading it away. They found several sites where they were able to degrade over 90%.

Then they took actual human skin from patients over 70 who had donated their skin, and they put this enzyme onto that skin. They were able to eliminate 55% of the CML on the skin, which basically reversed the skin's age down to that of a 31-year-old. This was from patients older than 70, just by putting this enzyme on the skin.

It's a groundbreaking demonstration of a combination of AlphaFold and what's called directed evolution, where you change the order of the DNA, which changes the structure of the protein, to test different proteins, do high-throughput screening, and ultimately make a novel protein that doesn't exist in nature today that can do something pretty profound for human health.

The next set of questions is, well, great, this enzyme is awesome. How are we going to get it into our bodies? How are we going to get it into that extracellular matrix? Is it going to be a cream, a shot, or a supplement? Could we eventually take an RNA shot that makes the protein inside our bodies and starts to do the degradation from within? A lot of questions still need to be answered, but it really, I think, lights a great path forward.

Chamath Palihapitiya

Amazing

David Friedberg

For these novel therapies that we're developing, and it's fucking awesome.

Chamath Palihapitiya

Amazing.

David Friedberg

I got all these joint pains in my hip and my shoulder now. Everything—you can feel yourself getting older.

Chamath Palihapitiya

Well, I'll tell you this right now: that will not be the first market. The first market will be cosmetic.

David Friedberg

Cosmetic skin, yeah.

Chamath Palihapitiya

It will be a $1 trillion market if you can create a cream.

David Friedberg

If you could put this enzyme literally on your skin and have it absorb—

Chamath Palihapitiya

On your face as a cream.

David Friedberg

Yeah.

Chamath Palihapitiya

Game over. That alone is $2 trillion.

David Friedberg

Unbelievable. But AI—let's just talk about applications of AI and why it's actually awesome. Everyone should be able to agree on that, and you can't be convinced by some foreign psyop. This is fucking awesome. This was AlphaFold—

Chamath Palihapitiya

It's amazing.

David Friedberg

—used to discover this thing, evolve it, and drive this outcome. Everyone can benefit from it. It's just so profound that we have this tool at our disposal in this day and age. I think it's pretty awesome. Anyway, thanks for sticking around for Science Corner.

Chamath Palihapitiya

Guys, I love you.

David Friedberg

All right, bro. Love you too.

speaker_6

Let your winners ride.

David Friedberg

And instead, we open source it to the fans, and they've just gone crazy with it.

David Friedberg

Love you, Bessie. Ice Queen of Kin Wah.

speaker_6

Let your winners ride. Let, let your winners ride.

David Friedberg

Besties are back.

speaker_6

Gold thirteen.

David Friedberg

That is my, uh, dog taking a piss in your driveway, Sacks. Wait, no, no, it's-

speaker_6

Oh, man.

David Friedberg

My habitasher will meet me at Blinks.

Chamath Palihapitiya

We should all just get a room and just have one big huge orgy because they're all just useless. It's like this, like, sexual tension that we just need to release somehow.

David Friedberg

Wet your feet. Wet your feet.

speaker_6

Wet your feet.

David Friedberg

We need to get merch. Besties are back. I'm going all in.

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