All-In

David Friedberg × Billy Evans

Evans says Holmes’s silence, despite no technical gag order, was her biggest mistake.Holmes was acquitted on patient-fraud counts but convicted of defrauding three investors and conspiracy; Evans says he understood the conspiracy charge allowed 10 additional investors into the $435 million restitution calculation, affecting sentencing.Hemantis aims to make Raman spectroscopy cheaper and more widely available, producing AI-ready biology datasets.

Martin Shkreli

Shkreli limits quantum’s edge to factoring and elliptic-curve logarithms; current machines lack quantum RAM.He calls industry spending speculative and expects analog optical computing to challenge Nvidia’s H100, B100, and B200 within 20 years.His pharmaceutical thesis favors mispriced discarded molecules; he calls AI drug discovery within five years “nonsense” and expects no AI-related drug in the next 10 years.

Chamath Palihapitiya × Jason Calacanis × David Sacks × David Friedberg

Anthropic’s outreach to roughly 20 religious leaders and Claude Constitution turn model consciousness, welfare and refusal behavior into a governance risk.OpenAI’s 700-plus papers reportedly averaged under three hours of compute per result, strengthening the machine-reasoning signal while cryptography concerns remain speculation rather than evidence.France’s 10-year yield above 5% and €43 billion austerity sharpen relative sovereign-risk concerns, while transactional agents could erode conventional software moats.

The White House Accord on Superintelligence turns six frontier companies’ voluntary pledge into board-level governance via internal controls, external audits and independent oversight, with FTC and SEC enforcement behind public commitments.It opens a market for professional auditors and compliance infrastructure, while open-weight models shift security spending toward cyber defense, compute and electricity; the next 12-18 months may test GPU-access policy.

Chamath Palihapitiya × Jason Calacanis × David Sacks × David Friedberg × Jake Paul × Drew Taggart × Alex Pall

Jake Paul is turning owned attention into distribution and talent infrastructure, citing 138 million Netflix viewers for the Mike Tyson event and 400 MVP fighters.His $100 million Anti Fund and The Chainsmokers’ fund target venture economics, but later tranches priced at two or three times earlier valuations without operating improvement leave realized DPI—not TVPI—as the test of Chamath’s bubble warning.

Daniel Ek

Spotify passed 700 million active users and 300 million premium subscribers; Daniel Ek became executive chairman January 1 and returned to building.Neko's $499 unit-economic-positive visit combines 53 blood markers, 6,000 images and clinician review in roughly an hour.Over 100,000 scans found serious, previously undiagnosed conditions in roughly 1% of members; population outcomes and budget effects remain unresolved.

Chamath Palihapitiya × Jason Calacanis × David Sacks × David Friedberg

Open-source token usage flipped from 20% to 80% in 12 weeks; if more than 60–70% of frontier tokens are replaceable, Anthropic’s S-1 revenue must be discounted.Meta’s free Muse hit #1 in the App Store with 3M downloads in roughly 10 days, challenging the App Store’s 30% rev-share as agents make services headless.Converging models push OpenAI and Anthropic toward higher-value applications, while their six-to-12-month frontier lead remains the central risk.

Luca Ferrari

Bending Spoons converts acquired product-market fit into a repeatable model, using 50+ proprietary tools and an approximately 800-person shared talent base to replace technology foundations.Historically consistent unlevered returns above 25% and debt costing about 9%, fully hedged and maturing in 2031, support the model, while limited customer synergies, competition and replication risk remain watchpoints.

Steve Hilton × Spencer Pratt

Hilton frames California’s gubernatorial race as a referendum on whether one-party control has converted unmatched assets into extreme costs, citing a nearly $1 million median home, a $65,000 median individual salary, and more than 420,000 regulations.His cuts and tax-relief package targets financially stressed former Democrats, while September 30’s debate tests whether support can broaden before business departures become a “stampede for the exits.”

Blake Scholl × Jason Calacanis

Boom’s 42 MW, water-free, behind-the-meter data-center system repurposes its Mach 1.7 engine core, with the first engine due next month, while vertical integration targets multiple gigawatts annually and more than 10 GW added to the grid over five years.Overture targets a $3,500 round-trip break-even fare and a four-year goal, but the actual service date remains uncertain as regulatory momentum accelerates.