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Sourcery · · 24 分钟

Brad Gerstner:每年100美元的检测,或可挽救5万条生命

Molly O'SheaBrad GerstnerJason ChangRob Goldberg

生物医药技术政策
播客
TL;DR
  • Brad Gerstner 的“登月计划”是把100美元的冠脉钙化CT变成“心脏的乳腺钼靶”,他称此举每年可挽救5万名美国人的生命,并为政府医疗支出节省200亿美元。 心脏病每年夺走80万美国人的生命,是全球头号杀手——但美国每年做4000万次乳腺钼靶检查,冠脉CT却只有100万次;他的目标是做到4000万次。“相当于美国每年结束一场乌克兰战争。”
  • 值得关注的催化剂是:在多次与 Dr. Oz 会面、并与国会山和白宫的领导人交谈后,Gerstner 表示,他认为用于诊断的CAC扫描将在“今年年底前”获批,并纳入 Medicaid 和 Medicare 报销。 机制很关键——“医生最终会按照保险覆盖范围所决定的医疗标准行医”——因此他把报销视为推动大规模筛查的路径。
  • Gerstner 对这段历史的解读是“监管俘获”(regulatory capture):他认为 Eisenhower 曾在椭圆形办公室心脏病发作,此后心脏健康成为国家议题;支架路线在华盛顿的游说竞争中击败了钙化CT路线。 由此形成的主流逻辑是——“监测胆固醇就够了……有心脏病再用支架解决。错。”Gerstner称这套逻辑最终胜出,尽管半数心脏病发作患者的胆固醇都处于正常区间。
  • Rob Goldberg 讲述哥哥 Dave 47岁去世的经历,成为反对传统筛查的关键案例:Dave 在因未确诊的心脏病引发室性心律失常、去世前5个月,刚通过一次运动心电图检查。 心电图存在4%的假阳性或假阴性率,而他长期高强度有氧运动让心脏形成了代偿——“它越泵越用力,越泵越用力,然后……就停了。”
  • Gerstner 表示,在被追问、突破“公司话术”后,Stanford、Harvard 和 Columbia 的预防心脏病科负责人给出的个人方案截然不同:30岁或35岁就给家人做CAC扫描,只要积分不是0,就把LDL压到40以下——而不是停留在约80-120的“绿色区间”。 Stanford 负责人承认,普筛不会消灭所有心脏病发作,“但你会消灭其中80%-90%。”
  • 分发模式是“买一送一”叠加放射科AI:Gerstner 提议以 Salesforce/Marc Benioff 为例,让员工免费做扫描、由公司按每次200美元付费,为 East Palo Alto 提供免费扫描;他称硅谷多家大型公司正在采用这一模式,其团队也在旧金山Super Bowl期间与NFL合作实施过。 Cleerly等放射科AI系统可以叠加在Siemens扫描仪上,进一步优化读片;Gerstner表示,他促成40-50名国会议员接受扫描——“这是一批目标高度集中的人群。”
摘要 · 为研究而整理的核心内容

1. 主张:100美元、15分钟,每年挽救5万人

  • 站在他一年前买下的移动CT车前,Gerstner算了一笔账:心脏病每年夺走80万美国人的生命,是全球头号杀手;把冠脉钙化CT变成“心脏的乳腺钼靶”,每年可挽救5万人——“相当于美国每年结束一场乌克兰战争”——并节省200亿美元政府医疗支出。
  • 筛查差距是他的核心论据:乳腺癌每年约夺走4万人生命,却有4000万次乳腺钼靶检查;心脏病夺走80万人生命,冠脉CT却只有约100万次。“他们已经为预防医学发明了完整打法,我想把这套打法复制到心脏健康上。”
  • 真正让方案具备可执行性的关键是:“没有斑块,就不会心脏病发作。”而高分“不是死刑”,因为他汀、依折麦布以及降低ApoB/LDL的方案,可以让心脏病发作“几乎完全可以预防”,这与脑癌不同。
  • Gerstner表示,心脏病发作预防中心有3项使命:提高认知、让筛查更容易获得,以及改变华盛顿的医疗标准。

2. Dave Goldberg之死:化验和心电图的反例

  • Rob Goldberg回忆,自己在墨西哥一栋度假屋的健身房里,发现弟弟倒在地上,当时正值朋友50岁生日聚会:“我的肾上腺素飙得太快,根本分不清那是他的心跳还是我的。”47岁的Dave、Sheryl Sandberg的丈夫,已经去世数小时;死因为室性心律失常。完整尸检显示,即便有顶级私人医疗团队,他仍患有未被诊断的心脏病。“他不是从跑步机上摔下来然后死的。”
  • 筛查失败才是这段经历的重点:Dave在5个月前的运动心电图检查中通过了测试,但心电图存在4%的假阳性或假阴性率;高强度有氧运动“训练他的心脏克服心脏病……然后最终它就停了”。他的外甥和外甥女当时只有7岁和10岁。Rob的结论是:“完全可以预防,也完全可以通过筛查发现。”
  • Molly自身的挫败感也印证了这一点——她父亲总拿“我的化验没问题,我刚做完全面检查”来搪塞;Gerstner给出他最尖锐的统计:“每年发生心脏病发作的人中,有一半的胆固醇处于正常区间。”

3. 胆固醇为何胜出:Gerstner所称的监管俘获

  • 他对现状的溯源是:“如果Bill Gurley在场,他会说这是监管俘获。”Gerstner表示,他相信Eisenhower曾在椭圆形办公室心脏病发作。约50年前,随着心脏健康成为国家议题,一条路线押注支架,另一条路线押注冠脉钙化CT扫描仪;“支架游说集团赢了”,于是留下了“监测胆固醇就够了……有心脏病就用支架解决。错”的主流逻辑。
  • 他也有意给阴谋论解读留出余地:“我不是说所有医生都参与了某个宏大阴谋……但现实中的证据——每年有80万人因此死亡——说明这还不够。”
  • Gerstner称,Stanford、Harvard和Columbia的预防心脏病科负责人在被追问、突破“公司话术”后,都表示会在家人30岁或35岁时做CAC扫描,只要积分不是0就使用他汀,并把LDL降到40以下——“远低于国家标准”所称约80-120的绿色区间。Gerstner自己曾以100的LDL处于“绿色区间”——“错。”

4. 检查路径:先做CAC,非0再做血管造影

  • 最常被问到的问题,答案是:35岁以上人群做CAC(100美元,进管约2分钟,非侵入性);有家族史或高胆固醇则是“必须、必须、必须”。若积分不为0,再做一项2000美元以上、轻度侵入性的血管造影,以绘制软斑块和狭窄情况。Cleerly等放射科AI系统如今可以叠加在扫描结果之上,提供更精细的读片;Gerstner说自己周五会重复做血管造影,并在Twitter上再次分享心脏影像——“没什么可怕的,数据就是力量。”
  • 他的保留意见也与批评者的说法一致:0分意味着没有钙化斑块,并不意味着完全没有斑块;扫描会漏掉软斑块,但软斑块可能继续钙化,因此“你已经走完90%以上的路”。按照Stanford预防心脏病科负责人的说法,普筛不会消灭所有心脏病发作,“当然不会。但你会消灭其中80%-90%。”
  • Jason Chang用安全带作比喻:“这实际上是少数几个替代结果就是死亡的检测之一……你拿到阴性结果仍可能猝死,但拿到阴性结果后,你依然可以补救。”
  • 移动CT车现场的技术员介绍,一天9小时可以完成33次扫描——“就是33条命”——而且积分分布跨度很大,“有些很严重,有些完全没有”;结果会交给心脏科医生,由医生致电患者。另一位发言者补充称,3-5年后是否复查,取决于积分、遗传状况和化验结果,随后举出一位牧师的父亲作为例子:他的“化验结果看起来非常好”,却死于大面积心脏病发作——“只看化验结果是不够的。”

5. 分发模式与华盛顿破局

  • 规模化路径是“买一送一”:Gerstner提出以Salesforce/Marc Benioff为例,让员工免费做扫描、由公司按每次200美元付费,从而为East Palo Alto以及那些“付不起、或对检查心存恐惧”的社区提供免费扫描;他称硅谷多家大型公司正在采用这一模式,其团队也在旧金山Super Bowl期间与NFL合作实施过。Gerstner表示,他促成40-50名国会议员接受扫描——“这是一批目标高度集中的人群”;目前已初步同意把移动CT车开到国会山。
  • 这项可以直接交易的判断仍带着原话中的谨慎程度:“但愿如此……我认为到今年年底”,用于诊断的CAC扫描将获批并纳入Medicaid和Medicare报销。在他看来,这一步之所以关键,是因为“医生最终会按照保险覆盖范围所决定的医疗标准行医。”
  • 零售端的验证来自他的Rosewood投资者日:“硅谷的知名CEO中,有人查出98%的堵塞,并在3周内装了3枚支架。”他的收尾是:“死于心脏病发作是最不值得的死法……少喝几杯Starbucks,省下100美元把检查做了。”
完整逐字稿
Molly O'Shea

Okay, we are here at the All-In Summit, at an amazing trailer that Brad Gerstner brought. You bought this how long ago?

Brad Gerstner

About a year ago.

Molly O'Shea

Okay. So, Brad, tell us what we're standing—

Brad Gerstner

Yeah.

Molly O'Shea

—in front of.

1. The Heart Screening Moonshot

Brad Gerstner

Yeah. So, we're standing in front of a mobile calcium CT scanner. Most of the folks who follow us on the All-In pod, the BG2 pod, et cetera, know that one of the moonshots I'm working on is that we have 800,000 people die in this country every year from heart disease. It's the number-one killer in the world.

If we turn the calcium CT scan into the mammogram for the heart, we will save 50,000 lives a year. That's like ending a Ukraine war every year in the United States. It will save the government $20 billion in care for people.

But most importantly, we're losing our most important friends, brothers, and dads at the prime of their lives to something that's totally preventable. This has a calcium CT scanner in it. We've had hundreds of people coming through here, and we've found scores over the last 2 days that most definitely have saved people's lives. It costs $100 and takes 15 minutes.

I lost my father too early, and my good friend here, Rob Goldberg, I want you to hear from him. This is the type of moonshot that we need to have. We're working with Washington. We want to get this covered by insurance so that we get 40 million people to take this scan.

Mammograms, which are super important in this country, have 40 million a year. CT scans, which are for the number-one killer, have 1 million a year. We need to have 40 million CT scans—

Molly O'Shea

Damn.

Brad Gerstner

—in this country every year. But, Rob, we're going to do a tag-team pod here.

Molly O'Shea

Too much, Brad.

Brad Gerstner

Yeah. You are a key inspiration. Your family was a key inspiration for me in wanting to do this, along with Jason Chang and the rest of the besties. Talk a little bit about how this touched your family.

2. A Preventable Family Loss

Rob Goldberg

Thank you, Brad, and thank you and Jason for doing this and for showcasing it. My unfortunate connection to this is that my brother, a number of our friends, and I were on vacation for a friend's 50th birthday—another bestie, Phil Deutsch. That afternoon, we saw him. We were all hanging out by the pool, and then, at 6:00 or 6:30, we couldn't find him.

My sister-in-law and I started looking for him, and we unfortunately found him collapsed in the gym of the house. My adrenaline was going so fast, I couldn't tell if it was his heartbeat or mine. I just started doing CPR, and we unfortunately brought him to the hospital. He had been dead for hours because he had undiagnosed heart disease.

My sister-in-law is Sheryl Sandberg. She wrote a book called Option B about his death and about grieving. He had top medical concierge doctors. This is a really important point.

My brother had passed a running EKG 5 months before he dropped dead from heart disease—from undiagnosed heart disease. Unfortunately, EKGs have a 4% rate of either false positives or false negatives. He had done so much cardio that he taught his heart to overcome the heart disease, so it was pumping harder and harder and harder. Then, eventually, when we were in Mexico, it just stopped.

He died of ventricular arrhythmia. I gave the report: We found him next to the treadmill. He did not fall off the treadmill and die. He died of heart disease. Thankfully, due to Sheryl, due to Chamath, and due to some other folks, we were able to bring him back so we could do a full autopsy and find his heart disease. But it's—

Brad Gerstner

And—

Rob Goldberg

—truly tragic, and it was completely unnecessary. He was 47.

Brad Gerstner

Yeah.

Rob Goldberg

My niece and nephew were 7 and 10. They're growing up without a biological father. They have a great stepfather now. But, as Brad just said, we are losing people in the prime of their lives who have no need to die from something that is completely preventable and screenable.

Brad Gerstner

And Dave was such a legend, so loved, and an inspiration in many ways for All-In and the bestie group. I mean, Chamath would say he was the original—who got everybody together for—

Rob Goldberg

He might argue a few points with everyone onstage, but yes.

Brad Gerstner

—to get together for poker. What better, more fitting way to honor Dave, but also to take this and say, “We can do something. We can be biased to action. We don't have to sit here as though we can do nothing. We have agency. Why aren't we doing 40 million CT scans a year? Why don't Americans know about this? Why are they all tracking their cholesterol and doing EKGs and thinking—

Rob Goldberg

Right.

Brad Gerstner

—or doing stress tests and thinking they're totally fine?” We've served people up some stuff that's just not accurate. This tells you dispositively: Do you have calcium in your arteries, yes or no? Calcium is a precursor and a predisposition to building plaque. You don't have a heart attack if you don't have plaque.

Rob Goldberg

Correct.

Brad Gerstner

To me, we started the Center for Heart Attack Prevention, and we have 3 missions with that. One is awareness. It's doing this, bringing a trailer so that more people talk about it and more people know about it.

I can tell you, while the scores are anonymous, we had scores from people who took their exam yesterday who are definitely in the danger zone. These people—

Rob Goldberg

It's amazing.

Brad Gerstner

No, here's the great thing.

Molly O'Shea

Yeah.

Brad Gerstner

Here's the great thing: A high score is not a death sentence—

Molly O'Shea

Mm.

Brad Gerstner

—because you can do something about it. Heart attacks are almost totally preventable. It's not like brain cancer, for which we don't have a lot of treatment. We can do everything with statins, with ezetimibe, et cetera. We can lower your ApoB, we can lower your LDLs, and we can get you on a path to heart health.

Number 1 is just awareness. Number 2 is making this more accessible to people. We need to have changes in Washington that make this the standard of care in the country. Cholesterol as a standard of care is ludicrous. We are way past this.

3. Why Cholesterol Missed The Problem

Molly O'Shea

How did we get to that? Why is cholesterol—how did cholesterol become the key—

Brad Gerstner

Yeah.

Molly O'Shea

—marker? Where did we go so wrong?

Brad Gerstner

If Bill Gurley were here—he is here somewhere—he'd say, “Regulatory capture.” Fifty years ago, heart health became a really national issue. I believe it was Eisenhower who had a heart attack in the Oval Office. There was a race in Silicon Valley to see who could solve heart health.

One path that people went down was to invent the stent. The other one was the calcium CT scanner. Who do you think won the lobby in Washington?

Molly O'Shea

The stent.

Brad Gerstner

The stent lobby won. They said, “Don't worry. Cholesterol is good enough to track. That's what we already do, and if you have a heart condition, we'll solve it with a stent.” Wrong. Wrong answer.

So here we are, many years later. My father died too early from heart disease, so I hijacked a session—the Science Corner—on the All-In Podcast in 2022. That's when I first started talking about this. Over the course of the last 3 to 4 years, we've made amazing progress.

Once I started talking about it, people went out and got their CACs, and I started getting hundreds and then thousands of letters from my dear friends to total strangers saying, “You saved my life. I found that I had…” I gave it for free at my investor day at the Rosewood Hotel on Sand Hill Road, and famous CEOs in Silicon Valley found 98% blockage and had 3 stents put in within 3 weeks of having the CAC done.

Molly O'Shea

Wow.

Brad Gerstner

This only costs $100. We have a live audience here.

Molly O'Shea

I know we do.

Brad Gerstner

So, I'm talking to the—

Molly O'Shea

And they're going, “Who are you?”

Brad Gerstner

It only costs $100.

Molly O'Shea

Please, no.

Brad Gerstner

It's noninvasive. It can be done in 10 minutes, and the fact that people don't know about this—

Molly O'Shea

Yeah.

Brad Gerstner

—is the highest ROI in health care, not only to the country, but to each of us—

Molly O'Shea

Right.

Brad Gerstner

—and to our friends. In our group, it's nonnegotiable.

Molly O'Shea

Right.

Brad Gerstner

Everybody has to get this. I appreciate your interest in this. To finish up on this, I say to my kids all the time—and this really inspired the Trump Accounts as well—

Molly O'Shea

Right.

Brad Gerstner

—we can sit around at the All-In Summit and talk about the problems. But what do we do in Silicon Valley so well? We start movements.

Rob Goldberg

Do things.

Brad Gerstner

We start companies. We do things. We have agency. We have a bias to action, and now we have a connection to Washington, D.C. You can bring these pillars of policy together, along with pillars of action and reeducation through podcasts and other things, to help people help themselves. I'm really thrilled you are here today.

Rob Goldberg

I just want to thank Brad for having me, but more importantly—much more importantly—what Brad and Jason are doing. Brad, overall, whether it's Trump Accounts or this, is the epitome of putting words to action, thoughts to action, and passion to action.

And I just love having you out in the world doing more of what you're doing. It's amazing. My brother would love this, obviously, were he here. You're continuing to do this to help others. You have a day job, and it's a pretty important day job, and you're doing that one pretty well, too. To spend the time to go out and do this is amazing. I just want to thank you and call you out for it, and the Trump Accounts as well.

Brad Gerstner

Yeah.

Rob Goldberg

It's just helping people, helping future generations with health and wealth. This is amazing.

Brad Gerstner

You're amazing. You know, I went to the heads of preventative cardiology at Stanford, Harvard, and Columbia, and they would start giving me their corporate speak.

Molly O'Shea

Yeah.

Brad Gerstner

And I said, “I don't want to hear the corporate speak. What do you do for yourself, your friends, and your family?” I would just push them on this. What do you do? Every single one of them said, “At 30 or 35, I have them all take a CAC. If they have a non-zero score, I get them on a statin. I get their LDLs below 40,” which is way below the national standards.

Rob Goldberg

Oh.

Brad Gerstner

The green zone in cholesterol, I think, is between 80 and 120.

Rob Goldberg

Right.

Brad Gerstner

So we would go get our cholesterol test, and it would say that we're in the green zone. I was in the green zone at 100. You feel good. You talk to your general practitioner, and they're saying, “You don't need a CAC. You're good. You're in the green zone. You run marathons. You do whatever. You're in incredible health.” Wrong.

Molly O'Shea

Right.

Brad Gerstner

Take control of your own heart health, right? It's the number-one killer in this country for a reason, because we're complacent about it.

Rob Goldberg

Right.

Brad Gerstner

If we're not complacent and we turn it into the mammogram for the heart, we're going to have a transformation in heart attack prevention in this country, and we're on a mission to see that through.

4. Making Heart Screening Standard

Molly O'Shea

So I have to ask, because with many new health protocols or treatments, and just testing in general, people get afraid of it. People might be afraid to know the results. They might be afraid to do it in general. How do you help break down those barriers, and how does this get brought into the standard of care for doctors?

Brad Gerstner

Yeah, no, it's a terrific question. I find that increasingly, because people have Oura rings on and Apple Watches on, we're breaking down the barriers to health data. People now want health data. Of course, there are those people who say, “I don't want to have the information.” I always say to people, data is power.

Rob Goldberg

Right.

Brad Gerstner

If you get information and you can't do anything about it, that's a real bummer. This, you can totally do something about, right? If you have 98% blockage, you get stents. If you don't have serious blockage, then you can get on a statin to reduce your LDLs, reduce your ApoB.

So because there is that power to do something about it, I find that many, many people want to do it. We have our tech over here who came all the way from Florida. He's also got 4 kids who each got their Trump account. We hooked them all up with $100 in their Trump accounts yesterday. But this guy knows what I'm saying: when people come here and are empowered with that information, they can now take action. They can now do something about it.

But yes, that's part of our mission. We have to explain to the country that there is nothing unsafe about this. This is effective for mass screening. I've met with Dr. Oz several times. I've talked to many leaders on Capitol Hill. I've talked to many people in the White House about it. I think by the end of this year—knock on wood—I think CAC scans for diagnostic purposes will be approved and covered by Medicaid and Medicare. If that happens, then that's how it becomes a standard of care.

Molly O'Shea

Mm.

Brad Gerstner

Because doctors ultimately practice according to the standard of care based on what's covered by insurance.

Jason Chang

I was just going to add that people being afraid of the results and afraid of testing—it's like, why do you wear a seatbelt? Why do you eat anything healthy? Why do you have greens? Why do you exercise at all? If you're trying to preserve your life, this is literally one of the few tests where the alternative is death.

Brad Gerstner

Yeah.

Jason Chang

It's not just, “Oh, I'm going to live 3 months longer when I'm 90.” This is literally—you could drop dead if you get a negative result, and if you get a negative result, you can still fix it. So it's: take the test and hopefully survive.

Brad Gerstner

Right.

A lot of people have asked me, and we could go through all the common questions.

Molly O'Shea

Yeah.

Brad Gerstner

One of the number-one questions I get is this: “Should I take the calcium CT scan or should I take the angiogram?”

5. Choosing The Right Heart Scan

The calcium CT scan—you’re in and out of the tube in about 2 minutes. It's not invasive at all. The angiogram puts dye in your bloodstream so that they can see more specifically the level of stenosis in your arteries. They can see the soft plaques, et cetera. That costs well over $2,000, and it's a little bit invasive. So it's not really needed for mass screening.

What I would recommend to people—and again, I'm not a doctor, and some people who are doctors think I have no business talking about this—but I'm an analyst. I can read all the information. By the way, I think we've been misled by the medical community about not doing this.

Jason Chang

Correct.

Brad Gerstner

My answer is: take the CAC if you're over 35. Obviously, if you have any family history or high cholesterol, then it's a must, must, must-do. But I would do it as a preventative measure anyway.

If you have a non-zero score, which demonstrates you have a propensity to gather plaque, then I would say take the angiogram. The angiogram then gives you a lot more information about soft plaques and the level of blockage, if any, in your arteries. Get a baseline.

Now we have great AIs, like Cleerly and other services that can sit on top of this. They're radiology AI systems that give you really refined readings. I did the Science Corner 3 years ago. I'm going back in on Friday, and I have almost no plaque, almost no stenosis, but I'm going back in on Friday. I'm having another angiogram just so I can biohack myself and share.

I shared on Twitter a picture of my heart through Cleerly, so that everybody could see exactly my level of stenosis. I will reshare that again after my angiogram on Friday.

Molly O'Shea

That's wonderful.

Brad Gerstner

Because there's nothing to be afraid of. Data is power, and I know because of all the messages that we've received, we've saved hundreds and hundreds of lives. If you save 1 life, it's enough. But the fact of the matter is, if we can get this done at scale in the country, the mammogram for the heart will save 50,000 lives a year.

Molly O'Shea

Incredible.

Brad Gerstner

Yes. Thank you.

Molly O'Shea

Thank you both so much. I really appreciate it. Where can you find the trailer next?

Brad Gerstner

Oh, so that's a great question. We bought this trailer because I was frustrated with all my friends in Silicon Valley saying, “Where do I get one of these?”

Molly O'Shea

Yeah.

Brad Gerstner

I rented a trailer for my investor day at the Rosewood.

Molly O'Shea

Mm.

Brad Gerstner

That was too much of a hassle, so I said, “Let's just buy one of these.” Then we had this idea that we could take it to companies around Silicon Valley, and we could do a buy-one, give-one.

Molly O'Shea

Mm.

Brad Gerstner

We could get Marc Benioff at Salesforce to give it to all of his employees for free, and then he would pay twice as much. So instead of paying $100, he would pay $200. Then we could go give free CAC scans in East Palo Alto and other neighborhoods where they couldn't afford it or they were afraid of it or whatever.

Now we have lots of companies in Silicon Valley. I don't want to dox any of the companies that are doing it. But I would say major companies in Silicon Valley are doing the buy-one, give-one. We did it with the NFL when the Super Bowl came to San Francisco.

Molly O'Shea

Oh, wow. Yeah.

Brad Gerstner

So, yeah, we're moving it all around, slowly but surely. I have a tentative agreement to take it to Capitol Hill and to give it to all members of Congress.

Molly O'Shea

They definitely need it.

Brad Gerstner

I know. By the way, I probably now am responsible for 40 or 50 members of the House and the Senate having taken the CAC scan, and I can tell you that they are a target-rich population.

People are dismissive of it until they find something or their family finds something, and then they become very devoted because they know that this is a lifesaver.

Molly O'Shea

Amazing. Okay, well, thank you guys so much.

Brad Gerstner

Yeah, it's so great.

Molly O'Shea

It's great to learn more about this. I really appreciate it.

Brad Gerstner

All right. Great. Thank you.

Jason Chang

Appreciate it. Thank you.

Molly O'Shea

I'll follow you.

Brad Gerstner

Okay, great.

Jason Chang

What's up, buddy?

Molly O'Shea

All right, we're going to go—

Brad Gerstner

Thank you so much.

Hopefully that was good.

6. Inside The Mobile Scanner

Molly O'Shea

Inside the CAC scan. Well, maybe he will.

Brad Gerstner

Okay. Here, you stand over here.

Molly O'Shea

Okay. Prenuvo scan.

Brad Gerstner

Yeah. It's great. Stand there. Yeah.

Molly O'Shea

So I spent a long time—

Brad Gerstner

Yeah. Right, right, right, right, right.

Molly O'Shea

In a machine.

Brad Gerstner

But by the way, Molly, we're in here. You said you did a Prenuvo scan, as I did.

Molly O'Shea

Yeah.

Brad Gerstner

Prenuvo scans take a long time, a lot of banging, et cetera. Remind us, how long are you in the tube here for the calcium CT scan?

Speaker 3

Yeah, for the cardiac scan, you're in here for maybe around 5 to 10 minutes—

Brad Gerstner

Right.

Speaker 3

Tops.

Brad Gerstner

In the trailer or on the bed?

Speaker 3

In the trailer.

Brad Gerstner

So how long are you on the bed for a calcium scan?

Speaker 3

On the bed for 5 minutes.

Brad Gerstner

5 minutes. So this is in and out, no noise. You get your results very quickly, et cetera, like I said. We can come in here. I mean—

Molly O'Shea

All right.

Brad Gerstner

This is pretty standard equipment. Siemens CT scanners—calcium CT scanners—have been around for a long time. Proven technology. We're now deep into generations of this technology. There are newer ones even than this one. But the reality is, you can run in and out of this. How many of these can we do a day?

Speaker 3

So yesterday, in about a 9-hour window, we did 33.

Brad Gerstner

Yes.

Speaker 3

So that was 33 lives.

Brad Gerstner

Exactly. And the results yesterday—we haven't shared them yet, so anonymously—but it looked like a distribution of the population writ large.

Speaker 3

Yeah. We have men, women, old, young.

Brad Gerstner

Yes. And some who have higher scores and some who have lower scores, like a distribution of scores.

Speaker 3

Yes, a wide distribution.

Brad Gerstner

Right.

Speaker 3

Some were severe, and some had none.

Brad Gerstner

Right. And so, with a calcium CT, zero means that you don't have any calcified plaque. Now, that doesn't mean you have no plaque, right? Because this does not read soft plaque. But what it does do is, when you get soft plaque, it calcifies, so it's a good indicator as to whether or not you are part of the population that is gathering plaque.

Some people criticize me and say, “Oh my gosh, you're telling people they're 100% safe.” No. In life, you are never 100% safe, but you get 90-plus percent of the way home by doing a CAC scan, and it's something that everybody can do. As you heard yesterday, we had some people who took it. I'm sure they had no idea they had severe scores. We'll share that information through a cardiologist.

The way this works is, we give them their CAC scan. He shares the scores with cardiologists, who will then call the patients, and they will work through whatever they need to work through. But—

Molly O'Shea

So how often should you be doing this, and how often—or how long—does it take for meaningful buildup to accrue?

Brad Gerstner

It just depends. Age has a huge impact on it. A 30-year-old is less likely to have plaque buildup, but if they do have plaque, it's a lot more telling because that means they're gathering plaque early. A 50- or 60-year-old is much more likely to have plaque, but we can tell by the quantity of plaque whether it's a problem or not.

The reality is, a lot of Americans—we just know it's the number one killer in America, okay? It's not like we're trying to create scare tactics for something that doesn't exist. This kills 800,000 people a year. It dwarfs the number of people who die every year from breast cancer, which is devastating, but I think we have about 40,000 people a year die of breast cancer. 800,000 people die of heart disease, and yet we have 40 times as many mammograms as we have calcium CTs.

I think breast cancer screening and mammograms invented the playbook for preventative medicine, and I would like to copy that playbook for heart health. If we do the same thing, we're going to save a lot of lives. It's very, very preventable.

Speaker 4

Dr. Mark Hyman and Dr. Sanjay Dixit actually brought up longitudinal data. To your point, one scan is great. Having some more in the future—3 to 5 years down the road, depending on your score, depending on your genetic outlook, and depending on your lab values—is important.

The pastor at my church had a father whose labs looked great. However, he had a massive, massive heart attack, completely unknown, and he never had one of these done. So going simply based on labs isn't enough, but having that longitudinal data based on genetics and labs is critical. It's very important.

7. Why Cholesterol Tests Fall Short

Molly O'Shea

I feel like the thing to overemphasize is that you cannot rely on cholesterol data or traditional data alone, because I brought this up to so many people. I've told my dad about this so many times.

Brad Gerstner

Yes.

Molly O'Shea

I'm a health nut. I'm like, “Dad, you have to get the calcium scan.”

Brad Gerstner

Yeah.

Molly O'Shea

“You have to get the calcium scan.” He's like, “Oh, my labs are fine.”

Brad Gerstner

Yes.

Molly O'Shea

“I'm good. I just went to the doctor.”

Brad Gerstner

Yes.

Molly O'Shea

“I did a full workup.” I'm like, “It's totally different. You have to get this done.”

Brad Gerstner

Yes.

Molly O'Shea

So, to overemphasize that, what did we miss with cholesterol and traditional health analysis?

Brad Gerstner

I have a great tweet on this that shows the red, green, and yellow of cholesterol. It turns out that half of the people who have heart attacks every year have cholesterol in the normal zone.

Molly O'Shea

Wow.

Brad Gerstner

Half of the people who have heart attacks every year have cholesterol in the normal zone. So the fact of the matter is, if you have a nonzero score, that means I have a predisposition to gather plaque. Then cholesterol becomes very important because that is the agent that carries the plaque to my arteries.

If I have plaque, I want to get my LDLs below 40. Remember, I think I told you the standard zone is 80 to 110 or 120, and so getting it below 40 is new information. Not a lot of cardiologists 5 or 10 years ago were saying this, and frankly, we didn't have the mechanisms to get it below 40.

But if you talk to the heads of preventive cardiology today at Stanford, Harvard, or Columbia, that's exactly what they would tell you to do. I'm not saying that all doctors are involved in a grand conspiracy by telling us to track our cholesterol. What I'm telling you is that the evidence on the street—that 800,000 people a year are dying of this—tells you that that's not enough. If it were enough, then we wouldn't have all these people dying.

Molly O'Shea

Mm.

Brad Gerstner

Do this as well. Even if you don't have insurance, this costs $100 out of pocket. Give up some Starbucks. Do what you need to do. Go talk to your friends. Get the $100 so that you can get this done.

It's far worse to have a dad or a mom die, and then look back at that and see how preventable it was. I've said it's a dumb way to die. Heart attacks are a dumb way to die because they're preventable, and you can do this.

I asked the head of preventive cardiology at Stanford, if everybody does this, are we going to eliminate all heart attacks? He said, of course not. But you'll eliminate 80% to 90% of them. You can eliminate 80% to 90% of the number one killer just by doing simple scans. So thank you for bringing attention to it. I really appreciate it, Molly.

Molly O'Shea

Happy to. Incredible work. Keep it up, honestly. Between this and the Trump Accounts, we can't—

Brad Gerstner

Let's go. Moonshots.

Molly O'Shea

We can't talk about it enough.

Brad Gerstner

Moonshots.

Molly O'Shea

Real moonshots.

Brad Gerstner

Yeah.

Molly O'Shea

Thank you.