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The a16z Show

The venture firm’s view of startups, AI, software, markets, company building, and the technological shifts creating new categories.

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164 EPISODESENTRACKED SHOW
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The a16z ShowEN · 41 min

How Truemed Is Incentivizing Americans to Invest in Prevention

Erik TorenbergJustin Mares

TrueMed’s differentiated wedge is turning qualified preventive interventions into tax-advantaged healthcare through letters of medical necessity and payment integrations with Eight Sleep, Peloton, Momentous, and Life Time Fitness.The model targets a structural mismatch in which consumers pay for prevention while insurers absorb enormous downstream costs, but subsidy reform, food quality, GLP-1 limitations, and regulatory capture remain essential risks to changing chronic-disease economics.

The a16z ShowEN · 59 min

Taking Bold Bets: NIH and the Future of Biomedical Science

Jay BhattacharyaErik TorenbergVineeta AgarwalaJorge Conde

Bhattacharya wants NIH managed like a venture portfolio, tolerating productive failures and funding younger, newer ideas instead of rewarding six-to-eight-year-old proposals and publication volume.The $50 million autism data-science program and cautious leucovorin and acetaminophen guidance show near-term execution, while replication, public-health trust, and AI-generated application volume remain critical reform risks.