Nathan Labenz

Nathan Labenz × Prakash Narayanan × Jeremie Harris × Edouard Harris × Steve Hou × Joel Borgen × Daniel McKinnon

Trump-Xi contact could create an AI-crisis hotline, but without pre-vetted verification tools, an incident could trigger a demand to shut down a large cluster.Hyperscalers charge at least two to three times neo-cloud GPU prices; Gamo’s o3 loop found a 91-kilobase deletion, while Opus 5.5 scored about 50% on RareBench versus roughly 10% for LIRICAL.

Jassi Pannu × Nathan Labenz

Jassi Pannu proposes keeping roughly 99% of biological data open while placing the estimated 1% of functional data linking pathogens to transmissibility, virulence, host range, or immune evasion into tiered trusted environments.Evo 2 and ESM-3 suggest selective exclusion can sharply reduce dangerous viral-task performance without broadly degrading other capabilities, but autonomous AI, private-lab opacity, and physical bottlenecks make mandatory DNA screening, passive surveillance, and defense-in-depth unresolved priorities.

Abhi Mahajan × Helen Toner × Jeremie Harris × @8teAPi × Nathan Labenz

The clearest near-term AI-biology opportunity is rescuing clinical value: Noetik combines pathology, 16-plex spatial proteomics, 19,000-gene spatial transcriptomics, and exome sequencing to find response biomarkers in trials where 97% of oncology candidates fail.Biology’s slow, ambiguous, expensive feedback makes rapid recursive improvement less likely, while AI-led R&D could still produce jagged acceleration; continuous risk measurement, infrastructure resilience, and the uncertain 2027–2030 horizon remain key variables.

Nathan Labenz × Kate Adamala

Synthetic biology could replace petrochemical production and improve medicine, but Adamala argues researchers should not create a self-replicating mirror cell.Its immune stealth and resistance to predators could make ecological containment impossible, with specialists expecting such a cell within a decade and no persuasive safety case yet.