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Invest Like the Best

Deep conversations with investors, founders, and operators about business quality, capital allocation, strategy, and enduring competitive advantage.

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90 EPISODESENTRACKED SHOW
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Invest Like the BestEN · 92 min

GLP-1s, Peptides, and The Trillion-Dollar Health Revolution

Patrick O'ShaughnessyAlex Karnal

GLP-1s exceeding $100 billion in annual revenue provide commercial proof for a potential trillion-dollar reduction in healthcare spending, shifting the opportunity from novel medicines to access, cost, and compliance.Price elasticity, longer dosing intervals, and oral delivery are rapidly expanding demand, while PCSK9 persistence and early cancer detection remain catalysts constrained by silent disease and false positives.