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No Priors

Elad Gil and Sarah Guo speak with leading AI engineers, researchers, and founders about model progress, markets at risk of disruption, and how commerce, culture, and society may change.

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No PriorsEN · 41 min

No Priors Ep. 144 | The 2026 AI Forecast with Sarah & Elad

Sarah GuoElad Gil

AI adoption is “blinding” among doctors, lawyers, and compliance teams, even as a weak Nvidia quarter could trigger panic; verticals such as coding, medical scribing, and legal software such as Harvey are consolidating.Monitor robotics timeline slippage and whether an AI IPO becomes a reflexive benchmark trade; Sarah forecasts somebody will make “hundreds of millions of dollars trading markets with LLMs” in 2026.

No PriorsEN · 41 min

No Priors Ep. 104 | With Flagship Pioneering CEO and Co-Founder Noubar Afeyan

Sarah GuoNoubar Afeyan

Noubar Afeyan’s Flagship Pioneering model treats parallel startup creation as a repeatable institution for underwriting uncertainty, using variation, selection and iteration rather than forecasting breakthroughs.Generate Biomedicines has more than 15 computationally designed antibody programs, but Phase III trials, FDA regulation, pricing power and platform funding remain decisive constraints, as Joule’s technically successful but economically unviable outcome demonstrates.