Dwarkesh Podcast

Dwarkesh Patel × Jacob Kimmel

Jacob Kimmel argues aging was weakly optimized by evolution, making partial longevity gains tractable, while NewLimit uses sparse perturbation data and models to search roughly 10^16 transcription-factor combinations.The commercial opportunity could span everyone, but first medicines are expected to add multiple healthy years rather than deliver immortality, with durability evidence currently limited to several weeks and reimbursement distorted by three-to-four-year US insurer churn.