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Moonshots

Conversations about exponential technologies, AI, longevity, space, robotics, and the entrepreneurs attempting unusually large missions.

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160 EPISODESENTRACKED SHOW
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MoonshotsEN · 125 min

Anthropic Files $965B IPO, Trump Signs AI Executive Order, and ChatGPT Crosses 1B Users | EP #262

Peter DiamandisEmad MostaqueDave BlundinDr. Alexander Wissner-Gross

Anthropic’s confidential IPO could make frontier AI a public-market asset class; Polymarket assigns a 60% chance of valuation above $1.8 trillion.ChatGPT’s reported one billion monthly users make distribution central as falling intelligence costs intensify the race for each user’s coordinating assistant.Trump’s voluntary 30-day review and DNA-screening debate leave governance unresolved while robotics and longevity attract sovereign-scale capital.

MoonshotsEN · 27 min

David Sinclair: GLP-1 Side Effect No One Talks About, AI in His Lab & Reversing Blindness | EP #251

Peter DiamandisDavid A. Sinclair

GLP-1s may deliver heart and brain benefits beyond weight loss, but Sinclair flags an unresolved blindness condition affecting roughly 20,000–30,000 U.S. cases annually.AI is accelerating molecule and cell analysis, while OSK and ER-100 remain preclinical; biotech investment still hinges on teams, cash, valuation, runway and clinical milestones.