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Moonshots
Conversations about exponential technologies, AI, longevity, space, robotics, and the entrepreneurs attempting unusually large missions.
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David Sinclair: GLP-1 Side Effect No One Talks About, AI in His Lab & Reversing Blindness | EP #251
Peter DiamandisDavid A. Sinclair
GLP-1s may deliver heart and brain benefits beyond weight loss, but Sinclair flags an unresolved blindness condition affecting roughly 20,000–30,000 U.S. cases annually.AI is accelerating molecule and cell analysis, while OSK and ER-100 remain preclinical; biotech investment still hinges on teams, cash, valuation, runway and clinical milestones.
How the New Administration Will Impact Crypto, AI & Tech Globally w/ Ben Horowitz & Salim Ismail
Ben HorowitzPeter DiamandisSalim Ismail
Washington’s shift from “complete war with the industry” to “aggressive pro-tech” could release blocked exits and revive crypto development, but Stargate’s quoted $500 million and $500 billion figures remain unclear while energy constrains AI infrastructure.DeepSeek’s roughly 100-times-lower token cost and AI-driven drug design strengthen the case for decentralized innovation, yet founders still need operational discipline, physical trials, and supply chains that remain overwhelmingly Chinese.